Synthetic analysis of associations between IL-10 polymorphisms and skin cancer risk
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Hongbo Zhao1, Jiaoli Yang1, Zhenzhen Yu1, Hui Shen1, Xinlin Huang1, Mi Zhang1, Teng Long1, Cailing A1 and Wenhui Wang2
1Department of Dermatology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China
2Department of Traditional Chinese Medicine, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China
Wenhui Wang, email: [email protected]
Keywords: IL-10; skin cancer; polymorphism; meta-analysis
Received: September 04, 2017 Accepted: December 04, 2017 Published: December 17, 2017
The current study was designed to quantitatively summarize the evidence for the strength of the associations between common IL-10 functional polymorphisms and skin cancer risk. Relevant publications concerning the associations between common IL-10 functional polymorphisms(–1082G>A, –819C>T and –592C>A) and skin cancer were retrieved by a comprehensive electronic literature search in PubMed, Web of Science, EBSCO, Embase, China National Knowledge Infrastructure, Wanfang, Chinese Biomedical Database (CBM). The odds ratio (OR) and 95% confidence interval (CI) were utilized to assess the strength of the relationship. A total of 26 studies including 4090 cases and 4133 controls (–1082G>A, 10 studies with 1809 cases and 1830 controls; –819C>T, 7 studies with 862 cases and 957 controls; –592C>A, 9 studies with 1419 cases and 1346 controls) were enrolled in the meta-analysis. Overall, the results revealed a borderline decreased risk of skin cancer in heterozygote model (OR = 0.82, 95CI = 0.67–1.00, p = 0.05). The subgroup analysis also presented similar association for non-melanoma skin cancer in heterozygote model (OR = 0.67, 95CI = 0.50–0.91, p = 0.01). Moreover, the further analysis based on the histological type of non-melanoma skin cancer indicated a significantly decreased risk of BCC in allele model (OR = 0.67, 95% CI = 0.50–0.91, p = 0.02) and dominant model (OR = 0.68, 95% CI = 0.48–0.98, p = 0.04). However, neither overall analysis nor subgroup analysis based on cancer subtype revealed a significant association of –1082G>A or –592C>A polymorphisms with skin cancer. The present study suggested a potential association between IL-10 –819C>T polymorphism and decreased risk of skin cancer, but a lack of association for –1082G>A and –592C>A polymorphisms. Further invalidation is urgently needed.
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