Oncotarget

Research Papers:

No differences in brain microstructure between young KIBRA-C carriers and non-carriers

Li Hu, Qunxing Xu, Jizhen Li, Feifei Wang, Xinghua Xu, Zhiyuan Sun, Xiangxing Ma, Yong Liu, Qing Wang and Dawei Wang _

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Oncotarget. 2018; 9:1200-1209. https://doi.org/10.18632/oncotarget.23348

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Abstract

Li Hu1,*, Qunxing Xu2,*, Jizhen Li3, Feifei Wang1, Xinghua Xu1, Zhiyuan Sun1, Xiangxing Ma1, Yong Liu4, Qing Wang1 and Dawei Wang1

1Department of Radiology, Qilu Hospital of Shandong University, Jinan 250012, China

2Medical Examination Center, Qilu Hospital of Shandong University, Jinan 250012, China

3Mental Health Center of Shandong Province, Jinan 250012, China

4Brainnetome Center, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China

*These authors contributed equally to this work

Correspondence to:

Dawei Wang, email: [email protected]

Qing Wang, email: [email protected]

Keywords: DKI; KIBRA; brain microstructure; young

Received: October 27, 2017     Accepted: December 04, 2017     Published: December 16, 2017

ABSTRACT

KIBRA rs17070145 polymorphism is associated with variations in memory function and the microstructure of related brain areas. Diffusion kurtosis imaging (DKI) as an extension of diffusion tensor imaging that can provide more information about changes in microstructure, based on the idea that water diffusion in biological tissues is heterogeneous due to structural hindrance and restriction. We used DKI to explore the relationship between KIBRA gene polymorphism and brain microstructure in young adults. We recruited 100 healthy young volunteers, including 53 TT carriers and 47 C allele carriers. No differences were detected between the TT homozygotes and C-allele carriers for any diffusion and kurtosis parameter. These results indicate KIBRA rs17070145 polymorphism likely has little or no effect on brain microstructure in young adults.


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