Oncotarget

Research Papers:

Clinical relevance of LINC00152 and its variants in western Chinese tuberculosis patients

Jing Li, Lijuan Wu, Weihua Guo, Juli Chen, Xuejiao Hu, Minjin Wang, Zhenzhen Zhao and Binwu Ying _

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Oncotarget. 2017; 8:115456-115468. https://doi.org/10.18632/oncotarget.23297

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Abstract

Jing Li1,*, Lijuan Wu2,*, Weihua Guo1, Juli Chen1, Xuejiao Hu2, Minjin Wang2, Zhenzhen Zhao2 and Binwu Ying2

1Department of Clinical Laboratory, Central Hospital of Panzhihua City, Panzhihua, Sichuan 617067, P. R. China

2Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China

*These authors have contributed equally to this work

Correspondence to:

Binwu Ying, email: docbwy@126.com

Keywords: tuberculosis; LINC00152; genetic variants; susceptibility; adverse drug reaction

Received: June 15, 2017     Accepted: December 03, 2017     Published: December 14, 2017

ABSTRACT

Recent studies indicate that the long intergenic non-coding RNA LINC00152 plays crucial roles in various human diseases. Here, we investigated whether levels of LINC00152 or its genetic variants correlate with the clinical features of tuberculosis (TB) in western Chinese patients. We genotyped the single nucleotide polymorphism LINC00152 rs80292941 in 476 TB patients and 475 healthy subjects using a custom-by-design 48-Plex SNPscan Kit, and measured relative levels of LINC00152 using RT-qPCR. We observed that LINC00152 levels were lower in TB patients than controls. Moreover, rs80292941 TT genotype carriers had the lowest LINC00152 levels among TB patients, and rs80292941 AA genotype carriers are more likely to suffer from hepatotoxicity induced by antituberculosis therapy [OR = 3.97, 95% = 1.53-10.13, p = 0.002]. Our findings strongly suggest that LINC00152 may promote TB progression and highlight rs80292941 single nucleotide polymorphism as a novel predisposition marker for antituberculosis drug-induced hepatotoxicity.


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