Protein dysregulation in graft versus host disease

Liren Qian, Delia Dima, Cristian Berce, Yu Liu, Ioana Rus, Lajos-Zsolt Raduly, Yi Liu, Bobe Petrushev, Ioana Berindan-Neagoe, Alexandru Irimie, Alina Tanase, Ancuta Jurj, Jianliang Shen and Ciprian Tomuleasa _

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Oncotarget. 2018; 9:1483-1491. https://doi.org/10.18632/oncotarget.23276

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Liren Qian1, Delia Dima2, Cristian Berce3, Yu Liu1, Ioana Rus3, Lajos-Zsolt Raduly2, Yi Liu1, Bobe Petrushev3, Ioana Berindan-Neagoe3, Alexandru Irimie3, Alina Tanase4, Ancuta Jurj3, Jianliang Shen1 and Ciprian Tomuleasa2,3

1Department of Hematology, Navy General Hospital, Beijing, PR China

2Department of Hematology, Ion Chiricuta Oncology Institute, Cluj Napoca, Romania

3Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania

4Department of Stem Cell Transplantation, Fundeni Clinical Institute, Bucharest, Romania

Correspondence to:

Ciprian Tomuleasa, email: [email protected]

Liren Qian, email: [email protected]

Keywords: allogeneic stem cell transplantation; biomarkers; proteins; graft versus host disease; exosomes

Received: September 28, 2017    Accepted: December 05, 2017    Published: December 15, 2017


Allogeneic hematopoietic stem cell transplantation is a well-established treatment for many malignant and non-malignant hematological disorders. As a frequent complication in up to 50% of all patients, graft-versus-host disease is still the main cause for morbidity and non-relapse mortality. Diagnosis is usually done clinically, even though confirmation by pathology is often used to support the clinical findings. Effective treatment requires intensified immunosuppression as early as possible. Although several promising biomarkers have been proposed for an early diagnosis, no internationally-recognized consensus has yet been established. Protein-based biomarkers represent an interesting tool since they have been recently reported to be an important regulator of various cells, including immune cells such as T cells. Therefore, we assume that protein dysregulation is important in the pathogenesis of acute graft versus host disease and their detection might be an possibility in the early diagnosis and monitoring. In this review, we aim to summarize the previous reports of protein biomarkers, focusing on the pathogenesis of the disease and possible implications in diagnostic approaches.

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