Oncotarget

Research Papers:

Catalpol protects mice against Lipopolysaccharide/D-galactosamine-induced acute liver injury through inhibiting inflammatory and oxidative response

Haogang Zhang, Ruichun Jia, Fujing Wang, Gongcai Qiu, Pengfei Qiao, Xunzheng Xu and Dequan Wu _

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Oncotarget. 2018; 9:3887-3894. https://doi.org/10.18632/oncotarget.23242

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Abstract

Haogang Zhang1,*, Ruichun Jia2,*, Fujing Wang1,*, Gongcai Qiu1, Pengfei Qiao1, Xunzheng Xu1 and Dequan Wu1

1Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China

2Department of Blood Transfusion, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China

*These authors contributed equally to this work

Correspondence to:

Dequan Wu, email: [email protected]

Keywords: lipopolysaccharide; D-galactosamine; acute liver injury; catalpol; TNF-α

Received: October 18, 2017     Accepted: December 01, 2017     Published: December 12, 2017

ABSTRACT

The purpose of this study was to investigate the protective effect of catalpol on Lipopolysaccharide (LPS)/D-galactosamine (D-gal)-induced acute liver injury in mice. The mouse model was established by injection of LPS and D-gal. Catalpol (2.5, 5, 10 mg/kg) were pretreated intraperitoneally 1 h before LPS and D-gal. The survival rate, AST, ALT, MDA, MPO activity, hepatic tissue histology, TNF-α level, and NF-κB activation were assayed. The results revealed that catalpol dose-dependently elevated the survival rate. Furthermore, catalpol reduced the activities of AST, ALT, MDA, and MPO. The production of TNF-α was also inhibited by treatment of catalpol. In addition, catalpol inhibited LPS/D-gal-induced NF-κB activation. The expression of Nrf2 and HO-1 were up-regulated by treatment of catalpol. These results indicated that pretreatment with catalpol could attenuate LPS/D-gal-induced acute liver injury in mice and the underlying mechanism may due to the inhibition of NF-κB signaling pathway and the activation of Nrf2 signaling pathway.


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