Coagulation cascade and complement system in systemic lupus erythematosus
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Yan Liang1,*, Shang-Bo Xie2,*, Chang-Hao Wu3, Yuan Hu4, Qin Zhang5,6, Si Li5,6, Yin-Guang Fan5,6, Rui-Xue Leng5,6, Hai-Feng Pan5,6, Hua-Bao Xiong4 and Dong-Qing Ye5,6
1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, PR China
2BGI-Shenzhen, Shenzhen, China
3Department of Biochemical Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK
4Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
5Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, PR China
6Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui, PR China
*These authors contributed equally to this work
Dong-Qing Ye, email: [email protected]
Keywords: systemic lupus erythematosus; coagulation cascade; complement system; biomarker; omics
Received: September 04, 2017 Accepted: November 16, 2017 Epub: December 11, 2017 Published: March 13, 2018
This study was conducted to (1) characterize coagulation cascade and complement system in systemic lupus erythematosus (SLE); (2) evaluate the associations between coagulation cascade, complement system, inflammatory response and SLE disease severity; (3) test the diagnostic value of a combination of D-dimer and C4 for lupus activity. Transcriptomics, proteomics and metabolomics were performed in 24 SLE patients and 24 healthy controls. The levels of ten coagulations, seven complements and three cytokines were measured in 112 SLE patients. Clinical data were collected from 2025 SLE patients. The analysis of multi-omics data revealed the common links for the components of coagulation cascade and complement system. The results of ELISA showed coagulation cascade and complement system had an interaction effect on SLE disease severity, this effect was pronounced among patients with excess inflammation. The analysis of clinical data revealed a combination of D-dimer and C4 provided good diagnostic performance for lupus activity. This study suggested that coagulation cascade and complement system become ‘partners in crime’, contributing to SLE disease severity and identified the diagnostic value of D-dimer combined with C4for lupus activity.
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