Oncotarget

Research Papers:

Prognostic values of long non-coding RNA MIR22HG for patients with hepatocellular carcinoma after hepatectomy

Yuan Dong, Weiwei Yan, Shi-Long Zhang, Mu-Zi-He Zhang, Yan-Ping Zhou, Hai-Hui Ling, Meng Ning, Yanling zhao _, Ang Huang and Ping Zhang

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Oncotarget. 2017; 8:114041-114049. https://doi.org/10.18632/oncotarget.23110

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Abstract

Yuan Dong1,*, Weiwei Yan2,*, Shi-Long Zhang1, Mu-Zi-He Zhang1, Yan-Ping Zhou1, Hai-Hui Ling1, Meng Ning1, Yanling Zhao1, Ang Huang3 and Ping Zhang4

1Department of Pharmacy, 302 Hospital of People’s Liberation Army, Beijing, People’s Republic of China

2Liver Cancer Center, 302 Hospital of People’s Liberation Army, Beijing, People’s Republic of China

3Non-Infectious Liver Disease Center, 302 Hospital of People’s Liberation Army, Beijing, People’s Republic of China

4Chinese Medicine Pharmacy of Integrative Medicine Center, 302 Hospital of People’s Liberation Army, Beijing, People’s Republic of China

*These authors have contributed equally to this work

Correspondence to:

Yanling Zhao, email: zhaoyl2855@126.com

Ang Huang, email: hanjpla@163.com

Ping Zhang, email: zhp1231@126.com

Keywords: MIR22HG; prognosis; hepatocellular carcinoma

Received: October 12, 2017    Accepted: November 22, 2017    Published: December 11, 2017

ABSTRACT

Hepatocellular carcinoma (HCC) is the fifth most frequently diagnosed cancer worldwide and the second most frequent cause of cancer death. The aim of this study is to identify the association between the expression of long non-coding RNA (lncRNA) MIR22HG and the clinical and tumor characteristics of patients with HCC, and to explore the prognostic significance of lncRNA MIR22HG on patients with HCC. We retrospectively reviewed 127 patients with HCC(42 female, 85 male) who were managed in our hospital between May 1st 2010 and June 30th 2016. The expressions of lncRNA MIR22HG were detected by real-time PCR. Prognostic factors were evaluated using Kaplan-Meier curves and Cox proportional hazards models. For the entire cohort of 127 patients, the normalized real-time PCR showed that the expression of lncRNA MIR22HG was lower in HCC tissues compared with corresponding nontumorous tissues. MTT assay showed that si-MIR22HG remarkably inhibited the proliferation tumor cells in three HCC cell lines including SMMC-7721, Huh-7 and Hep3B. Moreover, under-expression of MIR22HG was closely related to tumor encapsulation, microvascular invasion (MVI), and TNM stage. Cox proportional hazards analysis demonstrated that lncRNA MIR22HG under-expression was an independent risk factor associated with the prognosis of patients with HCC. In conclusion, we found that lncRNA MIR22HG expressed significantly lower in HCC tissues compared with non-tumorous tissues. Under-expression of lncRNAMIR22HG was an independent risk factor associated with the prognosis of patients with HCC.


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