Research Papers: Gerotarget (Focus on Aging):

RCAN1 in the inverse association between Alzheimer’s disease and cancer

Qiang Fu and Yili Wu _

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Oncotarget. 2018; 9:54-66. https://doi.org/10.18632/oncotarget.23094

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Qiang Fu1 and Yili Wu2,3,4

1 Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China

2 Department of Psychiatry, Jining Medical University, Jining, Shandong, China

3 Shandong Key Laboratory of Behavioral Medicine, Jining, Shandong, China

4 Collaborative Innovation Center for Birth Defect Research and Transformation of Shandong Province, Jining, Shandong, China.

Correspondence to:

Yili Wu, email:

Keywords: RCAN1; Alzheimer’s disease; cancer; inverse association; Gerotarget

Received: June 29, 2017 Accepted: November 17, 2017 Published: December 11, 2017


The inverse association between Alzheimer’s disease (AD) and cancer has been reported in several population-based studies although both of them are age-related disorders. However, molecular mechanisms of the inverse association remain elusive. Increased expression of regulator of calcineurin 1 (RCAN1) promotes the pathogenesis of AD, while it suppresses cancer growth and progression in many types of cancer. Moreover, aberrant RCAN1 expression is detected in both AD and various types of cancer. It suggests that RCAN1 may play a key role in the inverse association between AD and cancer. In this article, we aim to review the role of RCAN1 in the inverse association and discuss underlying mechanisms, providing an insight into developing a novel approach to treat AD and cancer.

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