Doxorubicin-fucoidan-gold nanoparticles composite for dualchemo-photothermal treatment on eye tumors

Hyejin Kim; Van Phuc Nguyen; Panchanathan Manivasagan; Min Jung Jung; Sung Won Kim; Junghwan Oh; Hyun Wook Kang

doi:10.18632/oncotarget.23092

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Doxorubicin-fucoidan-gold nanoparticles composite for dualchemo-photothermal treatment on eye tumors

Hyejin Kim, Van Phuc Nguyen, Panchanathan Manivasagan, Min Jung Jung, Sung Won Kim _, Junghwan Oh and Hyun Wook Kang

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2017; 8:113719-113733. https://doi.org/10.18632/oncotarget.23092

Metrics: PDF 1638 views | HTML 3852 views | ?

Abstract

Hyejin Kim1,*, Van Phuc Nguyen1,*, Panchanathan Manivasagan2,*, Min Jung Jung3, Sung Won Kim4, Junghwan Oh1,2 and Hyun Wook Kang1,2

1Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering, Pukyong National University, Busan, South Korea

2Department of Biomedical Engineering and Center for Marine-Integrated Biomedical Technology (BK 21 Plus), Pukyong National University, Busan, South Korea

3Department of Pathology, Kosin University College of Medicine, Busan, South Korea

4Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, Busan, South Korea

*These authors contributed equally to this work

Correspondence to:

Sung Won Kim, email: [email protected]

Junghwan Oh, email: [email protected]

Hyun Wook Kang, email: [email protected]

Keywords: doxorubicin; gold-nanoparticles; photothermal therapy; chemotherapy; eye tumor

Received: October 16, 2017 Accepted: December 01, 2017 Published: December 09, 2017

ABSTRACT

The current research demonstrates the feasible biomedical application of AuNPs coated with doxorubicin (Dox)-loaded fucoidan (Fu) for dual-chemotherapy and photothermal treatment (PTT) on eye tumors in vitro and in vivo. Marine-derived Fu was used as a capping agent to achieve high photostability for AuNPs, and Dox as a FDA-approved anti-cancer drug was added to induce chemotherapy. The synthesized Dox-Fu@AuNPs exhibited high cytotoxicity on the tumor cells and strong light absorption for temperature increase in vitro. After intratumoral injection of Dox-Fu@AuNPs in the rabbit eye tumors, PTT-assisted Dox-Fu@AuNPs entailed the complete removal of the eye tumors without recurrence for 14 days after the treatment. Photoacoustic image contrast from the tumor regions was enhanced due to selective light absorption by the administered Dox-Fu@AuNPs. Therefore, the proposed Dox-Fu@AuNPs can be a potential nano-theranostic material for treating and diagnosing the eye tumors.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 23092

Publication Alerts

Research Papers:

Doxorubicin-fucoidan-gold nanoparticles composite for dualchemo-photothermal treatment on eye tumors

Abstract