Meta-analysis of the prognostic value of p-4EBP1 in human malignancies

Tao Zhang, Jianrong Guo, Huili Li _ and Jiliang Wang

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Oncotarget. 2018; 9:2761-2769. https://doi.org/10.18632/oncotarget.23031

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Tao Zhang1, Jianrong Guo1, Huili Li1 and Jiliang Wang1

1Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China

Correspondence to:

Huili Li, email: [email protected]

Jiliang Wang, email: [email protected]

Keywords: p-4EBP1; prognosis; cancer; meta-analysis; malignancies

Received: July 02, 2017     Accepted: September 20, 2017     Published: December 07, 2017


Phosphorylated 4E-binding protein 1 (p-4EBP1) is the inactivated form of 4EBP1, which is a downstream mediator in the mTOR signaling pathway and a vital factor in the synthesis of some oncogenic proteins. This meta-analysis was conducted to assess the predicative value of p-4EBP1 expression in human malignancies. The PubMed and Embase databases were carefully searched. Articles comparing the prognostic worthiness of different p-4EBP1 levels in human malignancies were collected for pooled analyses and methodologically appraised using the Newcastle-Ottawa Scale (NOS). A total of 39 retrospective cohorts with an overall sample size of 3,980 were selected. Patients with lower p-4EBP1 expression had better 3-year (P < 0.00001), 5-year (P < 0.00001), and 10-year (P = 0.03) overall survival and better 3-year (P < 0.0001) and 5-year (P = 0.0005) disease-free survival. Subgroup analyses confirmed the unfavorable prognosis associated with p-4EBP1 overexpression. These findings were further validated by sensitivity analyses. Harbord and Peters tests revealed no publication bias within the included studies. It thus appears higher expression of p-4EBP1 indicates a poor prognosis in human malignancies.

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