Oncotarget

Clinical Research Papers:

The safety of fertility and ipsilateral ovary procedures for borderline ovarian tumors

Tong Lou, Fang Yuan, Ying Feng, Shuzhen Wang, Huimin Bai _ and Zhenyu Zhang

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Oncotarget. 2017; 8:115718-115729. https://doi.org/10.18632/oncotarget.23021

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Abstract

Tong Lou1,*, Fang Yuan2,*, Ying Feng1, Shuzhen Wang1, Huimin Bai1 and Zhenyu Zhang1

1Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

2Department of Obstetrics and Gynecology, the affiliated hospital of Qingdao University, Qingdao, China

*These authors contributed equally to this work

Correspondence to:

Huimin Bai, email: baihuimin2017@163.com

Zhenyu Zhang, email: zhangzhenyuzzy2016@163.com

Keywords: borderline ovarian tumor; BOT; recurrence; survival; treatment

Received: September 04, 2017     Accepted: November 17, 2017     Published: December 06, 2017

ABSTRACT

Objective: To explore the optimal treatment options for women with borderline ovarian tumors (BOTs).

Materials and Methods: The medical records of consecutive patients with BOTs in two academic institutions were retrospectively collected. The pertinent data, including clinicopathological characteristics and, treatment and prognostic information were evaluated.

Results: A total of 281 cases of BOTs were included in this analysis. For the entire series, the 5- year disease-free survival (DFS) and overall survival (OS) rates were 91.8% and 98.5%, respectively. In the multivariate analysis, reservation of the ipsilateral ovary (HR: 0.104 [95% CI, 0.036–0.304], p = 0.000) and FIGO stage II–III (HR: 6.811 [95% CI, 2.700–17.181], p = 0.000) were the independent risk factors for recurrence. Ovarian surface involvement (HR: 64.996 [95% CI, 4.054–1041.941], p = 0.003) was the only independent prognostic factor for OS. Lymphadenectomy and adjunct chemotherapy had no significant impact on patients’ recurrence and survival (recurrence: p = 0.332 and 0.290, respectively, survival: p = 0.896 and 0.216, respectively).

Conclusions: Fertility-sparing surgery with healthy ovarian preservation seems safe and feasible for young women who prefer fertility-sparing treatment. Ovarian cystectomy to conserve the affected ovary/ovaries without ovarian surface involvement may be cautiously performed under fully informed consent for young women with bilateral BOTs who strongly prefer fertility-sparing treatment and have no evidence of infertility. However, long-term follow-up is necessary due to the relapse susceptibility of the ovary.


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