Oncotarget

Research Papers:

Curcumin attenuates myocardial ischemia–reperfusion injury

Kun Liu, Honglin Chen, Qing-Sheng You, Qing Ye, Fei Wang, Shuo Wang, Shuang-Long Zhang, Kang-Jun Yu and Qi Lu _

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Oncotarget. 2017; 8:112051-112059. https://doi.org/10.18632/oncotarget.23002

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Abstract

Kun Liu1, Honglin Chen2, Qing-Sheng You1, Qing Ye3, Fei Wang1, Shuo Wang1, Shuang-Long Zhang1, Kang-Jun Yu1 and Qi Lu4

1Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, P.R. China

2School of Nursing, Nantong University, Nantong, P.R. China

3Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, P.R. China

4Department of Cardiology, Affiliated Hospital of Nantong University, Nantong, P.R. China

Correspondence to:

Qi Lu, email: ntluqi@sina.com

Keywords: curcumin; myocardial ischemia–reperfusion; inflammation

Received: September 19, 2017     Accepted: November 06, 2017     Published: December 06, 2017

ABSTRACT

Background: Cardiovascular diseases (CVDs) are at a badly high-risk of morbidity and mortality in the world.

Methods: Our study was attempted to investigate the cardioprotective role of curcumin. Hearts injury was assessed in isolated hearts and the rats of coronary artery ligated.

Results and Conclusions: The inhibition of pro-inflammatory cytokines was observed by curcumin in coronary artery ligated rats. ST segment was also reduced by curcumin. Triphenyltetrazolium chloride staining (TTC) staining and pathological analysis were also showed that curcumin could dramatically alleviate myocardial injury. Besides, the results in vitro also demonstrated that curcumin could improved the function of isolated hearts. Besides, the expressions of inflammation-related pathway in both rats and isolated hearts treated with curcumin were significantly decreased. The present study investigated the protective effects of curcumin on myocardial injury and its mechanism.


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