Curcumin attenuates myocardial ischemia–reperfusion injury
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Kun Liu1, Honglin Chen2, Qing-Sheng You1, Qing Ye3, Fei Wang1, Shuo Wang1, Shuang-Long Zhang1, Kang-Jun Yu1 and Qi Lu4
1Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, P.R. China
2School of Nursing, Nantong University, Nantong, P.R. China
3Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, P.R. China
4Department of Cardiology, Affiliated Hospital of Nantong University, Nantong, P.R. China
Qi Lu, email: email@example.com
Keywords: curcumin; myocardial ischemia–reperfusion; inflammation
Received: September 19, 2017 Accepted: November 06, 2017 Published: December 06, 2017
Background: Cardiovascular diseases (CVDs) are at a badly high-risk of morbidity and mortality in the world.
Methods: Our study was attempted to investigate the cardioprotective role of curcumin. Hearts injury was assessed in isolated hearts and the rats of coronary artery ligated.
Results and Conclusions: The inhibition of pro-inflammatory cytokines was observed by curcumin in coronary artery ligated rats. ST segment was also reduced by curcumin. Triphenyltetrazolium chloride staining (TTC) staining and pathological analysis were also showed that curcumin could dramatically alleviate myocardial injury. Besides, the results in vitro also demonstrated that curcumin could improved the function of isolated hearts. Besides, the expressions of inflammation-related pathway in both rats and isolated hearts treated with curcumin were significantly decreased. The present study investigated the protective effects of curcumin on myocardial injury and its mechanism.
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