The association analysis of TLR2 and TLR4 gene with tuberculosis in the Tibetan Chinese population
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Xin Xue1,2, Yi Qiu3, Dong Jiang4, Tianbo Jin5,6, Mengdan Yan5, Xikang Zhu6 and Yonglie Chu1
1Department of Pathogen Biology and Immunology, Xi’an Jiaotong University Health Science Center, Xi’an 710061, China
2The Fourth Internal Medicine, Xi’an Chest Hospital, Xi’an TB and Thoracic Tumor Hospital, Xi’an 710100, China
3The Second Internal Medicine, Xi’an Chest Hospital, Xi’an TB and Thoracic Tumor Hospital, Xi’an 710100, China
4Inner Mongolia Medical University, Hohhot 010010, China
5Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, School of Life Sciences, Northwest University, Xi’an 710069, China
6School of Medicine, Xizang Minzu University, Xianyang 712082, China
Yonglie Chu, email: firstname.lastname@example.org
Keywords: PTB; SNP; case-control study; Tibetan Chinese population
Received: March 29, 2017 Accepted: August 06, 2017 Published: December 06, 2017
Background: The present study was undertaken to explore the relationship of Toll-like receptor (TLR) 2, TLR4 genes polymorphisms with Pulmonary tuberculosis (PTB) risk in a sample of Chinese population.
Methods: For this study, we recruited 467 subjects with PTB and 504 healthy subjects from a Tibetan population living in near or in Xi’an, China. Association analyses of single-nucleotide polymorphisms (SNPs) in TLR2 and TLR4 were performed with SPSS Statistics (version 17.0), SNPStats, Haploview (version 4.2), and SHEsis software.
Results: The research results that is association analysis of pulmonary tuberculosis show there are two increased-risk SNPs (rs7696323, OR=1.32, 95%CI =1.08-1.62, P= 0.007; rs12377632, OR=1.30, 95%CI =1.09-1.55, P= 0.004) and three decreased-risk SNPs (rs3804099, OR=0.64, 95%CI =0.52-0.79, P= 1.95*10−5; rs3804100, OR=0.67, 95%CI =0.54-0.82, P= 0.0001; rs11536889, OR=0.54, 95%CI =0.42-0.69, P= 9.14*10−7).
Conclusions: We found that two SNPs are associated with increased PTB risk and three SNPs decreased PTB risk in the Chinese Tibetan population. Our findings demonstrate an association between TLR2 and TLR4 polymorphisms and PTB.
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