Genetic variation in CDH13 gene was associated with non-small cell lung cancer (NSCLC): A population-based case-control study
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Yingfu Li1,*, Chuanyin Li2,*, Qianli Ma3, Yu Zhang2, Yueting Yao2, Shuyuan Liu2, Xinwen Zhang2, Chao Hong2, Fang Tan1, Li Shi2 and Yufeng Yao2
1Department of Geriatrics, The No.1 Affiliated Hospital of Kunming Medical University, Kunming, 650032, China
2Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, 650118, China
3Department of Thoracic Surgery, The No.3 Affiliated Hospital of Kunming Medical University, Kunming, 650118, China
*These authors contributed equally to this work
Fang Tan, email: [email protected]
Li Shi, email: [email protected]
Yufeng Yao, email: [email protected]
Keywords: cadherin 13 (CDH13); single nucleotide polymorphisms (SNPs); non-small cell lung cancer (NSCLC); Chinese Han population
Received: October 11, 2017 Accepted: November 15, 2017 Published: December 05, 2017
Cadherin 13 (CDH13, T-cadherin, H-cadherin) has been identified as an anti-oncogene in various cancers. Recent studies have reported that downregulation of H-cadherin in cancers is associated with CDH13 promoter hypermethylation, which could be affected by the single nucleotide polymorphisms (SNPs) near CpG sites in the CDH13 promoter. In the current study, we investigated and analyzed the association of seven SNPs (rs11646213, rs12596316, rs3865188, rs12444338, rs4783244, rs12051272 and rs7195409) with non-small cell lung cancer (NSCLC) using logistic regression analysis. SNPs rs11646213, rs12596316, rs3865188 and rs12444338 are located in the promoter region, rs4783244 and rs12051272 are located in intron 1, and rs7195409 is located in intron 7. A total of 454 patients with NSCLC were placed into a NSCLC group and 444 healthy controls were placed into a control group, all participants were recruited to genotype the SNPs using Taqman assay. Our results showed that the allelic frequencies of rs11646213 were significantly different between NSCLC and control groups (P = 0.006). In addition, the association analysis of these SNPs stratified into NSCLC pathologic stages I+II and III+IV showed that the allelic frequencies rs7195409 had a significant difference between NSCLC pathologic stages I+II and III+IV (P = 0.006). Our results indicated that the rs11646213 and rs7195409 in CDH13 could be associated with NSCLC or its pathologic stages in the Chinese Han population.
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