Pleural MAC30 as a prognostic marker in NSCLC with malignant pleural effusion
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Yi Shan1,*, Hui Ding2,*, Junjie Lu1, Zhijun Ge1 and Yongfei Tan3
1Department of Critical Care Medicine, The Affiliated Yixing Hospital of Jiangsu University Yixing, Jiangsu 214200, China
2Department of Respiratory, The Affiliated Yixing Hospital of Jiangsu University Yixing, Jiangsu 214200, China
3Department of Cardiac & Thoracic Surgery, The Affiliated Yixing Hospital of Jiangsu University Yixing, Jiangsu 214200, China
*These authors have contributed equally to this work
Yongfei Tan, email: [email protected]
Keywords: MAC30; MPE; NSCLC; BPE; OS
Received: August 05, 2017 Accepted: September 20, 2017 Published: November 22, 2017
Over-expressed meningioma-associate protein (MAC30) in tissues was associated with malignant tumor differentiation, metastasis and poor prognosis. However, the attention of MAC30 in pleural effusion from lung tumor is insufficient. Our retrospective study was prepared to explore the clinical values on diagnosis and prognosis of MAC30 from malignant pleural effusion (MPE) in non-small cell lung cancer (NSCLC). Levels of MAC30 were confirmed in MPE from 48 NSCLC patients and in benign pleural effusion (BPE) from 45 controls via enzyme-linked immunosorbent assay (ELISA). The association of MAC30 in MPE with clinical significance was further determined. We found that the levels of MAC30 in MPE were obviously higher than those in BPE (p < 0.05). Moreover, with a cutoff point (17.5 ng/ml), we confirmed the sensitivity and specificity of MAC30 for MPE were 82.7% and 85.3% using ROC curve analysis. Indeed, longer overall survival (OS) was present in NSCLC patients with low MAC30 expression in MPE. Multivariate analysis explicated that elevated MAC30 in MPE was an independent prognostic factor for shorter OS of NSCLC. Our data suggests that MAC30 in pleural effusion could be a potential prognostic marker in NSCLC with MPE.
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