Oncotarget

Reviews:

Current research on head and neck cancer-associated long noncoding RNAs

Wei Song, Yimin Sun, Jie Lin _ and Xiaoqin Bi

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Oncotarget. 2018; 9:1403-1425. https://doi.org/10.18632/oncotarget.22608

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Abstract

Wei Song1, Yimin Sun1, Jie Lin2 and Xiaoqin Bi3

1State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China

2Department of Dental Anesthesiology, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan 610041, P.R. China

3Department of Head and Neck Oncology, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan 610041, P.R. China

Correspondence to:

Jie Lin, email: [email protected]

Xiaoqin Bi, email: [email protected]

Keywords: head and neck cancer; long noncoding RNA; cancer progression; clinical implication

Received: June 09, 2017     Accepted: September 08, 2017     Published: November 22, 2017

ABSTRACT

Head and neck cancers (HNC) are one of the ten leading cancers worldwide, including a range of malignant tumors arising from the upper neck. Due to the complex mechanisms of HNC and lack of effective biomarkers, the 5-year survival rate of HNC has been low and the mortality rate has been high in recent decades. Long noncoding RNAs (lncRNAs), noncoding RNAs longer than 200 bps, are a focus of current cancer research, closely related to tumor biology. LncRNAs have been revealed to be aberrantly expressed in various types of HNC, and the dysregulated lncRNAs participate in HNC progression and induce malignant behavior by modulating gene expression at diverse levels. This review will focus on the functions and molecular mechanisms of dysregulated lncRNAs in HNC tumorigenesis and progression, as well as their diagnostic, therapeutic or prognostic implications in HNC.


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