Current research on head and neck cancer-associated long noncoding RNAs
Metrics: PDF 1254 views | HTML 2126 views | ?
Wei Song1, Yimin Sun1, Jie Lin2 and Xiaoqin Bi3
1State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China
2Department of Dental Anesthesiology, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan 610041, P.R. China
3Department of Head and Neck Oncology, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan 610041, P.R. China
Jie Lin, email: [email protected]
Xiaoqin Bi, email: [email protected]
Keywords: head and neck cancer; long noncoding RNA; cancer progression; clinical implication
Received: June 09, 2017 Accepted: September 08, 2017 Published: November 22, 2017
Head and neck cancers (HNC) are one of the ten leading cancers worldwide, including a range of malignant tumors arising from the upper neck. Due to the complex mechanisms of HNC and lack of effective biomarkers, the 5-year survival rate of HNC has been low and the mortality rate has been high in recent decades. Long noncoding RNAs (lncRNAs), noncoding RNAs longer than 200 bps, are a focus of current cancer research, closely related to tumor biology. LncRNAs have been revealed to be aberrantly expressed in various types of HNC, and the dysregulated lncRNAs participate in HNC progression and induce malignant behavior by modulating gene expression at diverse levels. This review will focus on the functions and molecular mechanisms of dysregulated lncRNAs in HNC tumorigenesis and progression, as well as their diagnostic, therapeutic or prognostic implications in HNC.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.