Elevated CEA is associated with worse survival in recurrent rectal cancer
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Won Kyung Cho1, Doo Ho Choi1, Hee Chul Park1, Won Park1, Jeong Il Yu1, Young Suk Park2, Joon Oh Park2, Ho Yeong Lim2, Won Ki Kang2, Hee Cheol Kim3, Yong Beom Cho3, Seong Hyeon Yun3 and Woo Yong Lee3
1Department of Radiation Oncology, Seoul, Republic of Korea
2Division of Hematology-Oncology, Department of Medicine, Seoul, Republic of Korea
3Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
Doo Ho Choi, email: [email protected]
Keywords: CEA; rectal cancer; recurrence; survival
Received: May 18, 2017 Accepted: November 03, 2017 Published: November 18, 2017
This study investigated the prognostic impact of serum carcinoembryonic antigen (CEA) level in recurrent rectal cancer. We reviewed 745 patients who developed recurrence after curative treatment for rectal cancer between January 2000 and December 2012. Multivariate analyses for survival revealed that age > 60 years (p = 0.005), r-CEA ≥ 5 ng/ml (p < 0.001), disease free interval (DFI) < 12 months (p < 0.001), and palliative or conservative treatment (p < 0.001) were unfavorable factors.
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