F-box proteins in epigenetic regulation of cancer

Jia Shen _ and Charles Spruck

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Oncotarget. 2017; 8:110650-110655. https://doi.org/10.18632/oncotarget.22469

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Jia Shen1 and Charles Spruck1

1Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, San Diego, California, USA

Correspondence to:

Jia Shen, email: [email protected]

Charles Spruck, email: [email protected]

Keywords: F-box protein; SCF; E3 ubiquitin ligase; epigenetics; cancer

Received: September 12, 2017     Accepted: October 25, 2017     Published: November 16, 2017


Epigenetic abnormalities are now realized as important as genetic alterations in contributing to the initiation and progression of cancer. Recent advancements in the cancer epigenetics field have identified extensive alterations of the epigenetic network in human cancers, including histone modifications and DNA methylation. F-box proteins, the substrate receptors of SCF (SKP1-Cullin1-F-box protein) E3 ubiquitin ligases, can directly and indirectly affect the balance of epigenetic regulation. In this brief review, we discuss our current understanding of F-box proteins in cellular epigenetic regulation and how dysregulation of these processes contribute to cancer development.

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