Oncotarget

Research Papers:

Usefulness of plasma matrix metalloproteinase-9 levels in prediction of in-hospital mortality in patients who received emergent percutaneous coronary artery intervention following myocardial infarction

Jia-Jun Zhu, Qian Zhao, Hui-Juan Qu, Xiao-Mei Li, Qing-Jie Chen, Fen Liu, Bang-Dang Chen and Yi-Ning Yang _

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Oncotarget. 2017; 8:105809-105818. https://doi.org/10.18632/oncotarget.22401

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Abstract

Jia-Jun Zhu1,2,*, Qian Zhao1,2,*, Hui-Juan Qu1,2, Xiao-Mei Li1,2, Qing-Jie Chen1,2, Fen Liu1,2,3, Bang-Dang Chen1,2,3 and Yi-Ning Yang1,3

1Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China

2Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, China

3Clinical Research Institute of Xinjiang Medical University, Urumqi, China

*These authors have contributed equally to this work

Correspondence to:

Yi-Ning Yang, email: yangyn5126@163.com

Keywords: MMP-9; STEMI; in-hospital mortality; coronary artery intervention

Received: March 24, 2017    Accepted: September 21, 2017    Published: November 11, 2017

ABSTRACT

The aim of the present study was to investigate the predictive value of the plasma matrix metalloproteinase-9 (MMP-9) level at admission for in-hospital mortality in patients who received emergency percutaneous coronary intervention (PCI) following AMI. A single blood sample was collected at admission from 155 consecutive AMI patients who underwent emergent PCI. The plasma levels of MMP-9 value (528.9±191.6 ng/ml) were significantly higher in the patients who died (n=24) than in the survivors (385.4±236.0 ng/ml) during 14 days of hospitalization (P=0.005). The age, left ventricle wall motion score index (WMIS), Global Registry of Acute Coronary Events (GRACE) score and B-type natriuretic peptide (BNP) levels and GENSINI score at admission were significantly different between the patients who died and those who survived (P<0.001, P=0.004, P<0.001 and P<0.001, respectively). Cut-off concentrations for prediction of death was identified from receiver operator characteristic (ROC) curves. Using the cut-off value (MMP-9 level 398.2 ng/ml) to stratify the patients into two groups, the group with higher MMP-9 levels had a greater rate of in-hospital mortality than the lower level group (P<0.001). With the exception of the GRACE score, among all biomarkers measured, in stepwise multiple logistic regressions, only the MMP-9 level predicted the risk of in-hospital death after adjustment for all other risk factors (odds ratio 5.02, 95% CI 1.44 to 17.55). In conclusion, a higher MMP-9 level is an independent predictor of in-hospital death in AMI patients who received emergency PCI.


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