Oncotarget

Research Papers:

Trends and variations in mantle cell lymphoma incidence from 1995 to 2013: A comparative study between Texas and National SEER areas

Shuangshuang Fu, Michael Wang, David R. Lairson, Ruosha Li, Bo Zhao and Xianglin L. Du _

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Oncotarget. 2017; 8:112516-112529. https://doi.org/10.18632/oncotarget.22367

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Abstract

Shuangshuang Fu1, Michael Wang2, David R. Lairson3, Ruosha Li4, Bo Zhao5 and Xianglin L. Du1

1Department of Epidemiology, Human Genetics, and Environmental Science, School of Public Health, The University of Texas Health Science Center in Houston, Houston, Texas 77030, USA

2Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA

3Department of Management Policy and Community Health, School of Public Health, The University of Texas Health Science Center in Houston, Houston, Texas 77030, USA

4Department of Biostatistics, School of Public Health, The University of Texas Health Science Center in Houston, Houston, Texas 77030, USA

5Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA

Correspondence to:

Xianglin L. Du, email: Xianglin.L.Du@uth.tmc.edu

Michael Wang, email: miwang@mdanderson.org

Keywords: mantle cell lymphoma, incidence, SEER, Texas, disparity

Received: June 10, 2017     Accepted: October 02, 2017     Published: November 03, 2017

ABSTRACT

Background: Few studies have assessed mantle cell lymphoma (MCL) incidence trends in the U.S. National Cancer Institute’s Surveillance, Epidemiology and End Results (SEER) areas. Previous studies were 5 to 9 years old and MCL incidence in Texas remains unknown. This study updated the temporal trends and variations of MCL incidence in the SEER areas and compared them with counterpart data in Texas.

Results: From 1995 to 2013, there were 2, 435 and 5, 193 newly diagnosed MCL patients in Texas and SEER areas. Age-adjusted MCL incidence was 0.91 per 100,000 persons per year in Texas and 1.01 in SEER areas. MCL incidence increased steadily with an annual percent change (APC) of 2.56% in SEER areas and an APC of 2.16% in Texas. In SEER areas, APCs for MCL incidence were significantly different from zero in patients with advanced stage tumor (3.33%), male (2.71%), elderly patients ≥ 80 years old (4.21%) and non-Hispanic white patients (2.83%) (all P < 0.05). Similar patterns were found in Texas for both incidence rates and APCs.

Materials and methods: We identified all adult patients with newly diagnosed MCL in Texas Cancer Registry and SEER databases from 1995 to 2013. Age-adjusted incidence rates were calculated and negative binomial regression model was used to assess the factors associated with MCL incidence.

Conclusions: MCL incidence rates increased over time in both Texas and SEER areas, with increases being greater in male, non-Hispanic white, and elderly patient ≥70 years with advanced stage tumors. Texas has similar MCL incidence trends and disparities as the national SEER areas.


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