Genetic association between 1425G/A SNP in PRKCH and hypertrophic cardiomyopathy in a Chinese population
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Feng Ji1,*, Qun Liu2,*, Zeyu Feng3, Xinwei Han1 and Zhitong Li1
1Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
2Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
3Medical School of Nantong University, Nantong 226001, China
*These authors have contributed equally to this work
Feng Ji, email: email@example.com
Keywords: hypertrophic cardiomyopathy; genetics; polymorphism; hypertrophic obstructive cardiomyopathy; PRKCH
Abbreviations: HCM: hypertrophic cardiomyopathy; SCD: sudden cardiac death; PKC: protein kinase C; HOCM: hypertrophic obstructive cardiomyopathy; LVOTO: left-ventricular outflow tract obstruction
Received: August 13, 2017 Accepted: September 23, 2017 Published: October 31, 2017
Hypertrophic cardiomyopathy is a heterogeneous myocardial disorder with a broad spectrum of clinical presentation and morphologic features. Previous reports indicated that protein kinase C pathway as a major determinant of cardiac hypertrophy and heart failure. Population-based analyses of the association between PRKCH gene (encoded PKCη) and HCM has not been performed yet. The purpose of this study is to investigate the association of the nonsynonymous SNP (1425G/A) in PRKCH gene and hypertrophic cardiomyopathy in a Chinese population. 323 patients with HCM and 326 controls were examined using a case-control methodology. The 1425G/A SNP in PRKCH was genotyped by allele-specific real-time PCR assay. The 1425G/A SNP in PRKCH increased the risk of HOCM (hypertrophic obstructive cardiomyopathy) (OR=1.427, 95% confidence interval, 1.013 to 2.012, P=0.046) under a dominant model. After age- and sex-adjustment, the significant associations remained in HOCM (for GG +AG versus AA, OR= 2.497, 95% confidence interval, 1.01 to 6.17; P=0.047). The 1425G/A SNP in PRKCH increases the risk of hypertrophic obstructive cardiomyopathy in the Chinese population.
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