Research Papers:
Hesperitin enhances the ability of daunorubicin by coloading with MPEGPCL nanoparticles to induce apoptosis in gastric cancer
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Lin-Lin Zhen1, Tian-Heng Ma2, Jin-Hai Tang3, Tian-Fang Xia4, Jie Ge5, Wei-Ji Yuan5, Luo Chen5, Rang Wan5, Jing-Xiang Cheng5, Zhi-Kang Chen5, Zhi-Hua Cheng5 and Wei Song6
1Department of Gerontology, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an 223300, China
2Department of Gastroenterology, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an 223300, China
3Department of Gastroenterology, Jiangsu Provincial People’s Hospital, Nanjing 223300, China
4Department of Gastrointestinal Surgery, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an 223300, China
5Laboratory Medicines, Naning Biohelper Biotech Co., Ltd., Nanjing 223300, China
6Department of Thyroid Breast Surgery, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an 223300, China
Correspondence to:
Wei Song, email: [email protected], [email protected]
Keywords: hesperitin; daunorubicin; assembly method; gastric cancer; drug target
Received: June 24, 2017 Accepted: August 27, 2017 Published: October 31, 2017
ABSTRACT
Tumor targeting delivery system has been suggested as an attractive strategy against tumor progression. And combination chemotherapy is essential and effective in preventing gastric cancer. Hesperitin (HE) has been suggested to exhibit anti-cancer ability through inducing apoptosis in many tumors without obvious toxicity, and it exerts synergistic anti-cancer ability with other drugs. Clinical application of daunorubicin (DA) in treatment of various cancers has been restricted. Targeted delivery of anti-cancer drugs could reduce their off-target effects and promote their efficacy. In our paper, HE and DA co-loaded methoxy poly (ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) nanoparticles were prepared through an assembly method. The morphology, particle size (about 38 nm), zeta potential, release profile in vitro, cell proliferation and cytotoxicity effects were investigated. The results suggested that HE and DA could be efficiently loaded into MPEG-PCL nanoparticles synchronously, and in vitro study indicated that they could be released from the nanoparticles in an extended period. in vitro, HE/DA/MPEG-PCL exerted an enhanced cytotoxicity and high apoptosis-inducing activities of gastric cancer cells. Importantly, HE/DA/MPEG-PCL exhibited better cancer targeting and accumulation, enhancing the anti-tumor efficacy with little toxicity. Together, HE/DA/MPEG-PCL promoted the drug target on tumor site with preferable anti-tumor effects, which could be a promising therapeutic strategy against human gastric cancer.