Role of tandospirone, a 5-HT1A receptor partial agonist, in the treatment of central nervous system disorders and the underlying mechanisms
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Xuefei Huang1,*, Jing Yang2,*, Sijin Yang3,*, Shousong Cao4, Dalian Qin2, Ya Zhou1, Xiaoli Li5, Yun Ye1,6 and Jianming Wu2
1Department of Clinical Pharmacy, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China
2Laboratory of Chinese Materia Medica, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China
3Department of Cardiology and Neurology, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, 646000, China
4Laboratory of Cancer Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China
5Department of R&D, Sichuan CREDIT Pharmaceutical Ltd., Luzhou, Sichuan, 646000, China
6Department of Pharmacy, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China
*These authors have contributed equally to this work
Jianming Wu, email: firstname.lastname@example.org
Yun Ye, email: email@example.com
Keywords: tandospirone; 5-HT1A receptor; Parkinson's disease; schizophrenia; mechanisms
Received: July 26, 2017 Accepted: September 20, 2017 Published: October 27, 2017
5-hydroxytryptamine (5-HT, serotonin) is an important neurotransmitter in the modulation of the cognitive, behavioral and psychological functions in animals and humans. Among the fourteen subtypes of 5-HT receptor, 5-HT1A receptor has been extensively studied. Tandospirone, an azapirone derivative with strong and selective agonist effect on 5-HT1A receptor, has been used for the treatment of anxiety disorders especially generalized anxiety disorder for decades. Recently, tandospirone showed the efficacy in relieving the syndromes of social anxiety disorder and post-traumatic stress disorder as well as in potentiating the effect of antidepressants in the treatment of depression in both preclinical and clinical studies. More impressively, the beneficial effect of tandospirone has been revealed on improvement of motor dysfunction of Parkinson’s disease and cognitive deficits of schizophrenia either in monotherapy or in combination with other drugs. This review discusses the superiority of tandospirone in the treatment of the disorders and associated mechanisms in central nervous system from the literature.
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