LncRNAs and their role in cancer stem cells

Shusen Chen, Jiamin Zhu, Feng Wang, Zhifeng Guan, Yangyang Ge, Xi Yang and Jing Cai _

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Oncotarget. 2017; 8:110685-110692. https://doi.org/10.18632/oncotarget.22161

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Shusen Chen1,*, Jiamin Zhu1,*, Feng Wang1,*, Zhifeng Guan1, Yangyang Ge1, Xi Yang2 and Jing Cai1

1Department of Radiation Oncology, Nantong Tumor Hospital, Affiliated Tumor Hospital of Nantong University, Nantong, 226321, China

2Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China

*These authors have contributed equally to this work

Correspondence to:

Jing Cai, email: [email protected]

Xi Yang, email: [email protected]

Keywords: cancer stem cells; lncRNA; cancer biology

Received: June 14, 2017    Accepted: September 08, 2017    Published: October 30, 2017


Cancer stem cells (CSCs) play a vital role in the formation of tumors and have been studied as a target of anticancer therapy. Long non-coding RNAs (lncRNAs) are important in the genesis and progression of cancer. Various lncRNAs, such as ROR, HOTAIR, H19, UCA1, and ARSR, are involved in cancer stemness. These lncRNAs could regulate the expression of CSC-related transcriptional factors, such as SOX2, OCT4, and NANOG, in colorectal, prostate, bladder, breast, liver, and other cancer types. In this work, we review the progress of lncRNAs and cancer stem cells and discuss the potential signal pathways of lncRNAs in cancer stemness.

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