Research Papers:

Comparison between liver resection and liver transplantation on outcomes in patients with solitary hepatocellular carcinoma meeting UNOS criteria: a population-based study of the SEER database

Anli Yang, Weiqiang Ju, Xiaopeng Yuan, Ming Han, Xiaoping Wang, Zhiyong Guo, Xiaoli Wei, Dongping Wang, Xiaofeng Zhu, Linwei Wu _ and Xiaoshun He

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Oncotarget. 2017; 8:97428-97438. https://doi.org/10.18632/oncotarget.22134

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Anli Yang1,*, Weiqiang Ju1,*, Xiaopeng Yuan1,*, Ming Han1, Xiaoping Wang1, Zhiyong Guo1, Xiaoli Wei2, Dongping Wang1, Xiaofeng Zhu1, Linwei Wu1 and Xiaoshun He1

1Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China

2Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China

*These authors have contributed equally to this work

Correspondence to:

Linwei Wu, email: [email protected]

Xiaoshun He, email: [email protected]

Keywords: hepatocellular carcinoma; liver resection; liver transplantation; UNOS criteria

Received: July 03, 2017    Accepted: August 27, 2017    Published: October 30, 2017


Liver resection (LR) and liver transplantation (LT) are potential curative treatment methods for early hepatocellular carcinoma (HCC). However, it is controversial which treatment is more beneficial to patients with solitary HCC meeting the United Network for Organ Sharing (UNOS) criteria (single lesion, diameter≤50mm, no vascular invasion, no extrahepatic metastasis). We retrieved patients with solitary HCC meeting UNOS criteria diagnosed between 2004-2013 from the Surveillance Epidemiology and End Results (SEER) database. Multivariate Cox proportional hazards regression models were used to evaluate the impact of surgery type (LR/LT) on overall survival (OS) and disease-specific survival (DSS) in both the whole study group and subgroups. Our analyses show that LT Patients had significantly superior OS (Adjusted HR (95% CI): 0.39 [0.26-0.59]) and DSS (Adjusted HR (95% CI): 0.19 [0.10-0.35]) than those receiving LR, although compared with the 288 patients receiving LR, the 258 patients receiving LT had younger age, smaller tumor size, and higher fibrosis score (P<0.001). Subgroup analyses identified significant interactions between surgery type (LR/LT) and gender (Male/Female) in both OS (P=0.02) and DSS (P=0.02). Male patients benefit more from LT compared with LR in both OS (Adjusted HR (95% CI): 0.29 [0.18-0.47]) and DSS (Adjusted HR (95% CI): 0.10 [0.05-0.21]), but there is no difference between patients receiving LT and LR in female patients. In conclusion, LT is associated with superior survival than LR in patients with solitary HCC meeting UNOS criteria. Moreover, male patients benefits more from LT than LR, while female patients do not show different outcomes between the two procedures.

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