Oncotarget

Reviews:

Studies of lncRNAs in DNA double strand break repair: what is new?

Zhenzhen Wu and Yuming Wang _

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Oncotarget. 2017; 8:102690-102704. https://doi.org/10.18632/oncotarget.22090

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Abstract

Zhenzhen Wu1 and Yuming Wang1

1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China

Correspondence to:

Yuming Wang, email: wangyuming2006@hotmail.com

Keywords: DNA double strand break, DNA repair, lncRNA, cancer, chemoresistance

Received: August 21, 2017     Accepted: September 24, 2017     Published: October 26, 2017

ABSTRACT

The ‘junk DNA’ that has haunted human genetics for a long time now turns out to hold enormous hidden treasures. As species had their genomes and transcriptomes sequenced, there are an overwhelming number of lncRNA transcripts being reported, however, less than 100 of them have been functionally characterized. DNA damage is recognized and quickly repaired by the cell, with increased expression of numerous genes involved in DNA repair. Most of the time the studies have focused only on proteins involved in these signaling pathways. However, recent studies have implied that lncRNAs can be broadly induced by DNA damage and regulate DNA repair processes by various mechanisms. In this paper, we focus on recent advances in the identification and functional characterization of novel lncRNAs participating in DNA double strand break repair.


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PII: 22090