Oncotarget

Research Papers:

Physical exercises and weight loss in obese patients help to improve uric acid

Jun Zhou, Yu Wang, Fan Lian _, Dongying Chen, Qian Qiu, Hanshi Xu, Liuqin Liang and Xiuyan Yang

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Oncotarget. 2017; 8:94893-94899. https://doi.org/10.18632/oncotarget.22046

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Abstract

Jun Zhou1, Yu Wang2, Fan Lian1, Dongying Chen1, Qian Qiu1, Hanshi Xu1, Liuqin Liang1 and Xiuyan Yang1

1Department of Rheumatology & Clinical Immunology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China

2Department of Interventional Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China

Correspondence to:

Fan Lian, email: lianfan_l@hotmail.com

Keywords: hyperuricemia; BMI; physical activity; waist circumference

Received: July 13, 2017     Accepted: August 17, 2017     Published: October 25, 2017

ABSTRACT

Objective: to assess the impact of longitudinal change of the overweight and physical activity on hyperuricemia.

Methods: We performed a retrospective cohort study. Demographic information, clinical features, laboratory findings, body weight and physical exercises pattern were documented.

Results: Altogether 4678 cases of hyperuricemia were enrolled. The median aged males were most affected. Individuals in the middle age had the highest prevalence of being overweight (2501/3382, 74.0%). Middle aged with BMI≥25 kg/m2 were more likely to lose weight (963/2807, 34.3%). BMI and waist circumference control helped to reduce serum uric acid. Overweight population was more likely to use urate-lowering or uricosuric medication (3025/3382, 89.4%). Intermediate and heavy activity were associated with bigger SUA improvement. Patients in the age of 35-60 were more likely to do physical exercises than the others.

Conclusion: Being overweight is strongly associated with hyperuricemia. Successful weight control was correlated with significant uric acid reduction. Intermediate to heavy physical activity helps to reduce waist circumference and SUA. In the hyperuricemia population, obese, middle aged men were the most affected, and also the most likely to do more exercises and get their bodyweight back to normal.


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