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BANCR: a novel oncogenic long noncoding RNA in human cancers
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Yifan Zou1,3,*, Jianfa Li1,5,*, Yincong Chen3,*, Huizhong Xiao1, Fuyou Zhang1, Dan Yu2,*, Kewang Luo1,4
1Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People’s Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, China
2Longgang District Central Hospital of Shenzhen, Shenzhen, China
3Shantou University Medical College, Shantou, China
4People’s Hospital of Longhua, Shenzhen, China
5Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, China
*These authors have contributed equally to this work
Correspondence to:
Dan Yu, email: [email protected]
Kewang Luo, email: [email protected]
Keywords: lncRNA; BANCR; diagnostic biomarker; therapeutic target
Received: July 02, 2017 Accepted: September 21, 2017 Published: October 24, 2017
ABSTRACT
Long non-coding RNAs account for large proportion of non-coding transcripts in human genomes. Though they lack of open reading framework and cannot encode protein, they can control endogenous gene expression though regulating cell life activities. They serve as transcriptional modulator, posttranscriptional processor, chromatin remodeler and splicing regulator during the process of gene modification. Moreover, long non-coding RNAs were regarded as potential tumor markers for cancer diagnosis and prognosis. BANCR was identified as a cancer-promoting long non-coding RNA in melanoma tissues. Since then, increasing studies about BANCR in cancer progression were reported. BANCR was dysregulated in various cancers including melanoma, colorectal cancer, retinoblastoma, lung carcinoma and hepatocellular carcinoma, and increased BANCR expression cause poor prognosis and shorter survival rate of cancer patients. Furthermore, the functions and mechanisms of BANCR in cancer cells have been clarified. Here, we focus on the current research on the role of BANCR in the clinical management, progression and molecular mechanisms in human cancer.