Oncotarget

Reviews:

BANCR: a novel oncogenic long non-coding RNA in human cancers

Yifan Zou, Jianfa Li, Yincong Chen, Huizhong Xiao, Fuyou Zhang, Dan Yu _ and Kewang Luo

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Oncotarget. 2017; 8:94997-95004. https://doi.org/10.18632/oncotarget.22031

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Abstract

Yifan Zou1,3,*, Jianfa Li1,5,*, Yincong Chen3,*, Huizhong Xiao1, Fuyou Zhang1, Dan Yu2,*, Kewang Luo1,4

1Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People’s Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, China

2Longgang District Central Hospital of Shenzhen, Shenzhen, China

3Shantou University Medical College, Shantou, China

4People’s Hospital of Longhua, Shenzhen, China

5Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, China

*These authors have contributed equally to this work

Correspondence to:

Dan Yu, email: 23744801@qq.com

Kewang Luo, email: kewangluo@126.com

Keywords: lncRNA; BANCR; diagnostic biomarker; therapeutic target

Received: July 02, 2017     Accepted: September 21, 2017     Published: October 24, 2017

ABSTRACT

Long non-coding RNAs account for large proportion of non-coding transcripts in human genomes. Though they lack of open reading framework and cannot encode protein, they can control endogenous gene expression though regulating cell life activities. They serve as transcriptional modulator, posttranscriptional processor, chromatin remodeler and splicing regulator during the process of gene modification. Moreover, long non-coding RNAs were regarded as potential tumor markers for cancer diagnosis and prognosis. BANCR was identified as a cancer-promoting long non-coding RNA in melanoma tissues. Since then, increasing studies about BANCR in cancer progression were reported. BANCR was dysregulated in various cancers including melanoma, colorectal cancer, retinoblastoma, lung carcinoma and hepatocellular carcinoma, and increased BANCR expression cause poor prognosis and shorter survival rate of cancer patients. Furthermore, the functions and mechanisms of BANCR in cancer cells have been clarified. Here, we focus on the current research on the role of BANCR in the clinical management, progression and molecular mechanisms in human cancer.


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