Oncotarget

Research Papers:

Polymorphisms of rs1347093 and rs1397529 are associated with lung cancer risk in northeast Chinese population

Xiaoying Li, XueLian Li, Yangwu Ren, Zhihua Yin, Xiaowei Quan, Xiaoxia Xue and Baosen Zhou _

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Oncotarget. 2017; 8:94862-94871. https://doi.org/10.18632/oncotarget.22030

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Abstract

Xiaoying Li1,2, XueLian Li1,2, Yangwu Ren1,2, Zhihua Yin1,2, Xiaowei Quan1,2, Xiaoxia Xue3 and Baosen Zhou1,2

1Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China

2Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Department of Education, Liaoning, China

3The Third Center of Laboratory Technology and Experimental Medicine, China Medical University, Shenyang, China

Correspondence to:

Baosen Zhou, email: bszhou@cmu.edu.cn

Keywords: single nucleotide polymorphisms; MIR217HG; Gab1; lung cancer; susceptibility

Received: August 31, 2017    Accepted: September 23, 2017    Published: October 24, 2017

ABSTRACT

Lung cancer is one of the malignant tumors with the highest morbidity and mortality all over the world. Here we researched the association between two SNPs (rs1347093 in MIR217HG and rs1397529 in Gab1) and the risk of lung cancer in northeast Chinese population, including 825 cases and 766 controls. We carried out χ2 test, unconditional logistic regression analysis and crossover analysis to estimate the relationship between SNPs and lung cancer risk and the interaction between SNPs and smoking on susceptibility to lung cancer. The results indicated that rs1347093, rs1397529 polymorphisms were associated with lung cancer risk, especially with adenocarcinoma risk. Dominant genetic model of the rs1347093 was associated with reduced risk of lung cancer compared to CC genotype (AC+AA vs. CC: adjusted OR = 0.599, 95%CI = 0.418-0.858, P=0.005). For rs1347093, the similar result was found. Dominant genetic model of the rs1397529 was associated with reduced risk of lung cancer compared to AA genotype (AC+CC vs. AA: adjusted OR = 0.664, 95%CI = 0.491-0.897, P=0.008). There is no significant interaction between rs1347093, rs1397529 polymorphism and smoking on susceptibility to lung cancer. Our study might demonstrate that rs1347093 in MIR217HG and rs1397529 in Gab1 could be meaningful as the novel biomarker for lung cancer risk.


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