Meta-Analysis:
The roles of CD82 expression in gastric cancer: a meta and bioinformatics analysis
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Hua-Chuan Zheng1, Shuang Zhao1 and Bao-Cheng Gong1
1Department of Experimental Oncology and Animal Center, Shengjing Hospital of China Medical University, Shenyang 110004, China
Correspondence to:
Hua-Chuan Zheng, email: [email protected]
Keywords: CD82; gastric cancer; meta analysis; bioinformatics analysis
Received: July 04, 2017 Accepted: July 26, 2017 Published: October 23, 2017
ABSTRACT
CD82 encodes a transmembrane glycoprotein of tetraspanins family, and functions as a tumor metastasis suppressor. We performed a systematic meta and bioinformatics analysis through multiple online databases up to March 14, 2017. We¬ found down-regulated CD82 expression in gastric cancer, compared with normal mucosa (p < 0.05). CD82 expression was negatively with depth of invasion, lymph node and distant metastasis, TNM staging and dedifferentiation of gastric cancer (p < 0.05). A positive association between CD82 expression and favorable overall survival was found in patients with gastric cancer (p < 0.005). According to bioinformatics analysis, CD82 mRNA expression was higher in gastric cancer than normal tissues (p < 0.05). According to Kaplan-Meier plotter and TCGA database, we found that a higher CD82 expression was positively correlated with overall or progression- free survival rates of all cancer patients, even stratified by aggressive parameters or as an independent factor (p < 0.05). These findings indicated that CD82 expression might be employed as a potential marker to indicate gastric carcinogenesis and subsequent progression, even favorable prognosis.