Association between cadmium exposure and diabetes mellitus risk: a prisma-compliant systematic review and meta-analysis
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Ming Wu1,*, Jukun Song2,*, Chen Zhu3,*, Yadong Wang2, Xinhai Yin2, Guanglei Huang2, Ke Zhao2, Jianguo Zhu4, Zhuhui Duan5 and Lingkai Su5
1Department of Emergency Medicine, Guizhou Provincial People’s Hospital, Guizhou, China
2Department of Oral and Maxillofacial Surgery, Guizhou Provincial People’s Hospital, Guizhou, China
3Guiyang Hospital of Stomatology, Medical College, Zunyi Medical College, Guiyang, China
4Department of Urology, Guizhou Provincial People’s Hospital, Guizhou, China
5Affiliated Hospital of Stomatology, Medical College, Zhejiang University, Hangzhou, China
*These authors contributed equally to this work
Lingkai Su, email: [email protected]
Keywords: cadmium; diabetes mellitus
Received: July 03, 2017 Accepted: September 21, 2017 Published: October 20, 2017
Cadmium (Cd) is a pollutant with multiple adverse health effects: cancer, renal dysfunction, osteoporosis and fracture, and cardiovascular disease. Several population-based studies found an association between Cd and diabetes mellitus (DM), but this association is inconsistent with other research. We conducted meta-analysis to examine relationship between urinary/blood Cd exposure and DM risk. Pertinent studies were identified by searching PubMed and Embase databases, and combined odds ratio (OR) and corresponding 95% confidence interval (CI) were applied to evaluate said association. Meta-analysis showed that high U-Cd exposure is not correlated with DM risk (OR = 1.19; 95% CI = 0.83–1.71), and high B-Cd exposure is also not associated with increased risk of DM (OR = 1.16; 95% CI = 0.84-1.62) in the general population. Subgroup and sensitivity analysis proved similar results, with little evidence of publication bias. This meta-analysis suggests that high U-Cd/B-Cd exposure may not be risk factor for DM in general populations. However, large prospective studies are needed to confirm this finding.
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