Regulation of DNA replication-coupled histone gene expression
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Qianyun Mei1,*, Junhua Huang1,*, Wanping Chen1,2, Jie Tang1, Chen Xu1, Qi Yu1, Ying Cheng1, Lixin Ma1,2, Xilan Yu1,2 and Shanshan Li1,2
1Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, College of Life Sciences, Hubei University, Wuhan, Hubei 430062, China
2Hubei Key Laboratory of Industrial Biotechnology, College of Life Sciences, Hubei University, Wuhan, Hubei 430062, China
*These authors have contributed equally to this work
Xilan Yu, email: firstname.lastname@example.org
Shanshan Li, email: email@example.com
Keywords: DNA replication, histone gene transcription, cell cycle
Received: August 08, 2017 Accepted: September 20, 2017 Published: October 16, 2017
The expression of core histone genes is cell cycle regulated. Large amounts of histones are required to restore duplicated chromatin during S phase when DNA replication occurs. Over-expression and excess accumulation of histones outside S phase are toxic to cells and therefore cells need to restrict histone expression to S phase. Misregulation of histone gene expression leads to defects in cell cycle progression, genome stability, DNA damage response and transcriptional regulation. Here, we discussed the factors involved in histone gene regulation as well as the underlying mechanism. Understanding the histone regulation mechanism will shed lights on elucidating the side effects of certain cancer chemotherapeutic drugs and developing potential biomarkers for tumor cells.
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