Oncotarget

Case Reports:

Failure of ocular photodynamic therapy for secondary choroidal metastasis: a case report and literature review

Rui Hua, Wenya Li, Weiwei Wu, Jun Tao _ and Qing Peng

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Oncotarget. 2017; 8:95030-95035. https://doi.org/10.18632/oncotarget.21847

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Abstract

Rui Hua1, Wenya Li2, Weiwei Wu3, Jun Tao4 and Qing Peng5

1 Departments of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, P.R. China

2 Departments of Thoracic Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, P.R. China

3 Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA

4 Department of Ophthalmology, The 4th People’s Hospital of Shenyang, Shenyang, Liaoning, P.R. China

5 Department of Ophthalmology, Minhang Hospital, Fudan University, Shanghai, P.R. China

Correspondence:

Jun Tao, email:

Qing Peng, email:

Keywords: choroidal metastasis; photodynamic therapy; deterioration; lung cancer; angiography

Abbreviations: PDT- photodynamic therapy; SD-OCT- spectrum domain optical coherence tomography; FFA- fundus fluorescein angiography; MRI- magnetic resonance imaging

Received: June 06, 2017 Accepted: October 05, 2017 Published: October 16, 2017

Abstract

The choroid is the most common site for intraocular metastatic disease. Photodynamic therapy (PDT) can effectively destroy malignant tissue and induce anti-tumor activity. Recent publications support its use as an effective therapy for the treatment of choroidal metastases, especially in the subfoveal region, resulting in subsequent vision preservation or improvement. Here, we introduce a case of choroidal metastasis, secondary to primary lung cancer. The progression of choroidal metastasis after PDT was followed up using spectral domain optical coherence tomography with point-to-point follow-up. Unfortunately, both the choroidal metastasis and serous retinal detachment increased after PDT. Since the mechanism underlying the therapeutic effect of PDT on choroidal metastasis is still not fully understood, deeper investigations into its safety, underlying molecular mechanisms, and treatment effects are critical for further PDT clinical usage in intraocular choroidal metastases.


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