Clinical Research Papers:
Intravoxel incoherent motion diffusion-weighted MR imaging of the liver using respiratory-cardiac double triggering
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Jinning Li1,*, Caiyuan Zhang1,*, Yanfen Cui1, Huanhuan Liu1, Weibo Chen2, Guilong Wang2 and Dengbin Wang1
1Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
2Philips Healthcare, Shanghai 200233, China
*These authors contributed equally to this work
Dengbin Wang, email: firstname.lastname@example.org
Keywords: intravoxel incoherent motion, diffusion-weighted imaging, liver, repeatability, respiratory-cardiac double triggering
Received: August 02, 2017 Accepted: September 22, 2017 Published: October 11, 2017
To investigate the influence of respiratory-cardiac double triggering (RCT) on intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) for the liver, twelve healthy volunteers underwent liver DWI twice respectively with respiratory triggering (RT) and RCT schemes. Signal-to-noise ratios (SNRs) of the images, values, repeatability (evaluating with within-subject coefficient of variation), and variability of quantitative parameters, including apparent diffusion coefficient (ADC), pure diffusion coefficient (D), perfusion fraction (f), and perfusion-related diffusion coefficient (D*), were evaluated for each DWI sequence. Results showed that the use of RCT scheme significantly enhanced SNRs (P < 0.001), improved the measurement precision (P ≤ 0.023) and repeatability (P ≤ 0.009) of ADC, D, and f values, decreased the variability of ADC and D values (P ≤ 0.015). Furthermore, this improvement was not completely confined to the left liver lobe, but also observed for the right liver lobe. Moreover, the precision of D* values in the right lobe (P < 0.001) and its repeatability in the left lobe (P = 0.002) were also significantly improved. Thus, our findings suggest that RCT is a more effective physiological scheme for improving SNRs, the precision, repeatability, and variability of quantitative parameters than RT for IVIM-DWI in the liver.
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