Research Papers: Pathology:

Effects of cerebral perfusion pressure on regional cerebral blood flow in dogs with acute epidural hematoma: quantitative evaluation with contrast-enhanced ultrasound

Hongwei Cheng, Xiang Mao, Zonggang Hou, Jian Xu, Shuyu Hao, Huan Li and Baiyun Liu _

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Oncotarget. 2017; 8:93373-93381. https://doi.org/10.18632/oncotarget.21795

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Hongwei Cheng1,*, Xiang Mao1,2,5,*, Zonggang Hou3,5,*, Jian Xu2, Shuyu Hao3,5, Huan Li3,5 and Baiyun Liu2,3,4,5

1 Department of Neurosurgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China

2 Neurotrauma Laboratory, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China

3 Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China

4 Nerve Injury and Repair Center of Beijing Institute for Brain Disorders, Beijing, China

5 China National Clinical Research Center for Neurological Diseases, Beijing, China

* These authors contributed equally to this work

Correspondence to:

Baiyun Liu, email:

Keywords: cerebral perfusion pressure, regional cerebral blood flow, intracranial pressure, contrast-enhanced ultrasound, Pathology Section

Received: July 31, 2017 Accepted: September 22, 2017 Published: October 11, 2017


To discuss the relationship between the regional cerebral blood flow (rCBF) and cerebral perfusion pressure (CPP) and the effect of CPP on rCBF in different spaces in an experimental animal model. As the ICP increased, the CPP and rCBF (A × β value measured by CEU) decreased to varying degrees. The rCBF1 and rCBF2 were well correlated with the CPP. At the same CPP, rCBF1 decreased significantly than the level of rCBF2 (p < 0.01). Six healthy cross-breed dogs, both males and females, weighing 18.3 ± 1.6 kg, were selected to establish models of increased intracranial pressure (ICP) via the installation of an epidural latex sacculus. The calculated CPP was in accordance with the ICP through the formula CPP = MAP - ICP, and contrast-enhanced ultrasound (CEU) was used to instantly measure the rCBF 1 and 2 cm around the sacculus edge. The relationship between rCBF 1 cm (rCBF1) and 2 cm (rCBF2) around the sacculus edge and the CPP was analyzed. As the ICP increased, the CPP and rCBF both decreased. The rCBF and the CPP had a linear relationship, but the perfusion pressure did not necessarily determine all parts of the rCBF. The rCBF was different in different spaces: the farther away from the injured site, the smaller the effect on the rCBF.

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