Oncotarget

Research Papers:

Identification of potential prognostic ceRNA module biomarkers in patients with pancreatic adenocarcinoma

Lili Zhao and Bingrong Liu _

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Oncotarget. 2017; 8:94493-94504. https://doi.org/10.18632/oncotarget.21783

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Abstract

Lili Zhao1 and Bingrong Liu2

1Department of Gastroenterology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China

2Department of Gastroenterology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China

Correspondence to:

Bingrong Liu, email: bingrliu@foxmail.com

Keywords: hallmark gene, pancreatic adenocarcinoma, microRNAs, competitive endogenous RNA, long non-coding RNAs

Received: July 26, 2017     Accepted: September 08, 2017     Published: October 10, 2017

ABSTRACT

Accumulating evidence suggested that long non-coding RNAs (lncRNAs) can function as competing endogenous RNAs (ceRNAs) to interact with other RNA transcripts and ceRNAs perturbation play important roles in cancer initiation and progression including pancreatic adenocarcinoma (PAAD). In this study, we constructed a PAAD-specific hallmark gene-related ceRNA network (HceNet) using paired genome-wide expression profiles of mRNA, lncRNA and miRNA and regulatory relationships between them. Based on “ceRNA hypothesis”, we analyzed the characteristics of HceNet and identified a ceRNA module comprising of 29 genes (12 lncRNAs, two miRNAs and 15 mRNAs) as potential prognostic biomarkers related to overall survival of patients with PAAD. The prognostic value of ceRNA module biomarkers was further validated in the train (Hazard Ratio (HR) =1.661, 95% CI: 1.275–2.165, p<1.00e-4), test (HR=1.546, 95% CI: 1.238-1.930, p<1.00e-4), and entire (HR=1.559, 95% CI: 1.321-1.839, p<1.00e-4) datasets. Our study provides candidate prognostic biomarkers for PAAD and increases our understanding of ceRNA-related regulatory mechanism in PAAD pathogenesis.


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