Research Papers:

A case-control study on risk factors of breast cancer in Han Chinese women

Li-Yuan Liu, Fei Wang, Shu-De Cui, Fu-Guo Tian, Zhi-Min Fan, Cui-Zhi Geng, Xu-Chen Cao, Zhen-Lin Yang, Xiang Wang, Hong Liang, Shu Wang, Hong-Chuan Jiang, Xue-Ning Duan, Hai-Bo Wang, Guo-Lou Li, Qi-Tang Wang, Jian-Guo Zhang, Feng Jin, Jin-Hai Tang, Liang Li, Shi-Guang Zhu, Wen-Shu Zuo, Li-Xiang Yu, Yu-Juan Xiang, Fei Zhou, Liang Li, Qiang Zhang, Qin-Ye Fu, Zhong-Bing Ma, De-Zong Gao, Yu-Yang Li, Lu Liu, Chun-Miao Ye, Yong-Jiu Wang, Wen-Zhong Zhou and Zhi-Gang Yu _

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Oncotarget. 2017; 8:97217-97230. https://doi.org/10.18632/oncotarget.21743

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Li-Yuan Liu1, Fei Wang1, Shu-De Cui2, Fu-Guo Tian3, Zhi-Min Fan4, Cui-Zhi Geng5, Xu-Chen Cao6, Zhen-Lin Yang7, Xiang Wang8, Hong Liang9, Shu Wang10, Hong-Chuan Jiang11, Xue-Ning Duan12, Hai-Bo Wang13, Guo-Lou Li14, Qi-Tang Wang15, Jian-Guo Zhang16, Feng Jin17, Jin-Hai Tang18, Liang Li19, Shi-Guang Zhu20, Wen-Shu Zuo21, Li-Xiang Yu1, Yu-Juan Xiang1, Fei Zhou1, Liang Li1, Qiang Zhang1, Qin-Ye Fu1, Zhong-Bing Ma1, De-Zong Gao1, Yu-Yang Li1, Lu Liu1, Chun-Miao Ye1, Yong-Jiu Wang1, Wen-Zhong Zhou1 and Zhi-Gang Yu1

1Department of Breast Surgery, The Second Hospital of Shandong University, Jinan, Shandong, 250033, China

2Department of Breast Surgery, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan, 450008, China

3Department of Breast Surgery, Shanxi Cancer Hospital, Taiyuan, Shanxi, 030013, China

4Department of Breast Surgery, The First Hospital of Jilin University, Changchun, Jilin, 130021,China

5Breast Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China

6Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China

7Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong, 256603,China

8Department of Breast Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, 100021, China

9Department of General Surgery, Linyi People’s Hospital, Linyi, Shandong, 276003, China

10Breast Disease Center, Peking University People's Hospital, Beijing, 100044, China

11Department of General Surgery, Beijing Chaoyang Hospital, Beijing, 100043, China

12Breast Disease Center, Peking University First Hospital, Beijing, 100034, China

13Breast Center, Qingdao University Affiliated Hospital, Qingdao, Shandong, 266003, China

14Department of Breast and Thyroid Surgery, Weifang Traditional Chinese Hospital, Weifang, Shandong, 261041, China

15Department of Breast Surgery, The Second Affiliated Hospital of Qingdao Medical College, Qingdao Central Hospital, Qingdao, Shandong, 266042, China

16Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China

17Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, China

18Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, 210009, China

19Department of Breast and Thyroid Surgery, Zibo Central Hospital, Zibo, Shandong, 255036, China

20Department of Breast Surgery, Yantai Yuhuangding Hospital, Yantai, Shandong, 264000, China

21Breast Cancer Center, Shandong Cancer Hospital, Jinan, Shandong, 250117, China

Correspondence to:

Zhi-Gang Yu, email: [email protected]

Keywords: breast cancer, Han Chinese, risk factors, case-control study

Received: April 09, 2017     Accepted: August 26, 2017     Published: October 09, 2017


This study aimed to investigate risk factors associated with breast cancer among Han Chinese women in northern and eastern China. A matched case-control study involving 1489 patients with breast cancer and 1489 controls was conducted across 21 hospitals in 11 provinces in China, from April 2012 to April 2013. We developed a structured questionnaire to record information from face-to-face interviews with participants. Student’s t-tests, Pearson’s chi-square tests, and univariate and multivariate conditional logistic regression analyses were used to identify variables with significant differences between the case and control groups. Ten variables were identified (P<0.05): location, economic status, waist-to-hip ratio, menopause, family history of breast cancer, present life satisfaction, sleep satisfaction, milk products, behavior prevention scores, and awareness of breast cancer. We identified a comprehensive range of factors related to breast cancer, among which several manageable factors may contribute to breast cancer prevention. Further prospective studies concerning psychological interventions, sleep regulation, health guidance, and physical exercise are required. A screening model for high-risk populations should be put on the agenda.

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