Oncotarget

Clinical Research Papers:

ACTION (acute coronary treatment and intervention outcomes network) registry-GWTG (get with the guidelines) risk score predicts long-term mortality in acute myocardial infarction

Tongtong Yu, Chunyang Tian, Jia Song, Dongxu He, Zhijun Sun and Zhaoqing Sun _

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Oncotarget. 2017; 8:102559-102572. https://doi.org/10.18632/oncotarget.21741

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Abstract

Tongtong Yu1, Chunyang Tian1, Jia Song1, Dongxu He1, Zhijun Sun1 and Zhaoqing Sun1

1Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, P.R.China

Correspondence to:

Zhaoqing Sun, email: sunzhaoqing@vip.163.com

Keywords: ACTION, risk score, long-term mortality, acute myocardial infarction, percutaneous coronary intervention

Received: August 18, 2017     Accepted: September 24, 2017     Published: October 11, 2017

ABSTRACT

This study aimed to test the predictive performance of the updated ACTION, GRACE, and CADILLAC risk scores (RS’s) for long-term mortality in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). The study included individuals from 2 independent cohorts: derivation cohort (N = 1901) and validation cohort (N = 728). From the derivation cohort, we used Cox regression analysis to determine that the updated ACTION, GRACE, and CADILLAC RS’s were associated with long-term mortality. The concordance (C) statistics of the 3 RS’s were 0.682, 0.703 and 0.734, respectively. We used the validation cohort to validate the results. Moreover, the discriminatory performance of the updated ACTION RS for predicting long-term mortality in both the respective derivation and validation cohorts was similar to the discriminatory performance of the GRACE and CADILLAC RS’s (ACTION vs. GRACE: z = 0.684, p = 0.494; ACTION vs. CADILLAC: z = 1.638, p = 0.101) and (ACTION vs. GRACE: z = 0.460, p = 0.646; ACTION vs. CADILLAC: z = 0.290, p = 0.772). Despite their development over a decade ago, GRACE and CADILLAC RS’s maintain good performance for predicting the long-term mortality of AMI patients undergoing PCI. As a new risk model, the updated ACTION RS also predicts long-term mortality, and its discriminatory performance is similar to that of the GRACE and CADILLAC RS’s.


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