Oncotarget

Research Papers:

The effects of FK1706 on nerve regeneration and bladder function recovery following an end-to-side neurorrhaphy in rats

Wansheng Gao _, Xiangfei He, Yunlong Li and Jianguo Wen

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Oncotarget. 2017; 8:94345-94357. https://doi.org/10.18632/oncotarget.21718

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Abstract

Wansheng Gao1, Xiangfei He1, Yunlong Li1 and Jianguo Wen1

1Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, 450052, China

Correspondence to:

Wansheng Gao, email: gao_wansheng726@163.com

Keywords: FK1706, end-to-side neurorrhaphy, immunophilin ligands, neurogenic bladder, nerve regeneration

Received: July 28, 2017    Accepted: August 28, 2017    Published: October 10, 2017

ABSTRACT

Background: Immunophilin ligands are neuroregenerative agents binding to FK506 binding proteins, by which stimulate recovery of neurons in a variety of injury nerves. FK1706 is a novel immunophilin ligand which has neuroprotective and neuroregenerative effects but without immunosuppressive activity. At present, most reports about FK1706 in ameliorating nerve injury and functional recovery are limited to cavernous nerve injury and erectile function recovery. This study aimed to demonstrate the effects of FK1706 on nerve regeneration and bladder function recovery following an end-to-side neurorrhaphy in rat models.

Method: The numbers of regenerated myelinated axons of the pelvic parasympathetic nerve (PPN) in the three groups’ rats (FK1706 + ETS, ETS and control groups) were evaluated. Their intravesical pressure (IVP), S100β and growth associated protein 43 (GAP43) expressions were also compared.

Results: In FK1706 + ETS group, 90% the rats showed that the frequency of FG labeled neurons was larger than the 3.5 cutoff value, 100% the rats showed that the frequency of FG-FB double-labeled neurons was larger than the 5.5 cutoff value. The average maximum of IVP in FK1706 + ETS group reached 76.3% of the value in control group. Their average number of myelinated axons of regenerated PPN reached 80% of the amount in control group. The nerve regeneration-associated markers data indicated that the expression level of S100β and GAP43 in FK1706 + ETS group was approximately 2-fold higher than that of ETS group (P < 0.05).

Conclusions: After end-to-side neurorrhaphy, FK1706 effectively enhanced the nerve regeneration and bladder function recovery.


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