TERT rs2736098 (Ex2-659G>A) polymorphism and cancer susceptibility: evidence from a comprehensive meta-analysis
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Tingyuan Pang1,*, Minjie Zhou2,#, Rumin Liu2, Jia Luo2 and Renfei Xia2
1Department of Pharmacy, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou City, 510000, P.R. China
2Department of Kidney Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou City, 510000, P.R. China
Renfei Xia, email: [email protected]
Keywords: TERT, rs2736098, polymorphism, cancer, meta-analysis
Received: August 18, 2017 Accepted: September 20, 2017 Published: October 09, 2017
Increasing researches have been performed regarding the relationship between TERT rs2736098 and cancer risk, but no consensus has been reached about the relationship. Here, we conducted this updated meta-analysis, aiming to comprehensively evaluate the role of TERT rs2736098 in cancer risk. We systematically searched potential relevant articles through PubMed, EMBASE, CNKI, and WanFang database before August 2017. A total of 33 studies with 18685 cases and 23820 controls were finally included in the current meta-analysis. We then adopted odds ratios (ORs) and 95% confidence intervals (CIs) to analyze the contributions of TERT rs2736098 to cancer risk. We found that the TERT rs2736098 polymorphism was associated with risk of cancer in overall analysis (AA vs. GG: OR = 1.26, 95% CI = 1.09–1.47; AA vs. AG/GG: OR = 1.22, 95% CI = 1.09–1.36; AA/AG vs. GG: OR = 1.13, 95% CI = 1.02–1.24; A vs. G: OR = 1.11, 95% CI = 1.04–1.20). Furthermore, in analysis stratified by cancer type, ethnicity, control source, quality score, and Hardy-Weinberg equilibrium (HWE) in controls, we found increased risk of cancer among lung cancer, bladder cancer, breast cancer, colorectal cancer, other cancers, Asians, hospital-based subgroup, score > 9 group, as well as controls agreement with HWE group. Despite some limitations, the current meta-analysis represented the largest and the most comprehensive investigations, with the strongest conclusion than ever before. To further explicit the association between TERT rs2736098 and cancer risk, more well-design case-control studies with larger sample size are warranted in the future.
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