Oncotarget

Clinical Research Papers:

Genetic predisposition toward suicidal ideation in patients with acute coronary syndrome

Hee-Ju Kang, Kyung-Yeol Bae, Sung-Wan Kim, Il-Seon Shin, Young Joon Hong, Youngkeun Ahn, Myung Ho Jeong, Jin-Sang Yoon and Jae-Min Kim _

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Oncotarget. 2017; 8:94951-94958. https://doi.org/10.18632/oncotarget.21661

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Abstract

Hee-Ju Kang1, Kyung-Yeol Bae1, Sung-Wan Kim1, Il-Seon Shin1, Young Joon Hong2, Youngkeun Ahn2, Myung Ho Jeong2, Jin-Sang Yoon1 and Jae-Min Kim1

1Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea

2Department of Cardiology, Chonnam National University Medical School, Gwangju, Korea

Correspondence to:

Jae-Min Kim, email: jmkim@chonnam.ac.kr

Keywords: acute coronary syndrome, suicidal ideation, polymorphism, serotonin transporter, longitudinal study

Received: July 02, 2017     Accepted: September 21, 2017     Published: October 07, 2017

ABSTRACT

The genetic predisposition toward suicidal ideation has been explored to identify subgroups at high risk and to prevent suicide. Acute coronary syndrome (ACS) is associated with an increased risk of suicide, but few studies have explored the genetic predisposition toward suicide in ACS populations. Therefore, this longitudinal study explored the genetic predisposition toward suicidal ideation in ACS patients. In total, of 969 patients within 2 weeks after ACS, 711 were followed at 1 year after ACS. Suicidal ideation was evaluated with the relevant items on the Montgomery–Åsberg Depression Rating Scale. Ten genetic polymorphisms associated with serotonergic systems, neurotrophic factors, carbon metabolism, and inflammatory cytokines were examined. Associations between genetic polymorphisms and suicidal ideation within 2 weeks and 1 year of ACS were investigated using logistic regression models. The 5-HTTLPR s allele was significantly associated with suicidal ideation within 2 weeks of ACS after adjusting for covariates and after the Bonferroni correction. TNF-α –308G/A, IL-1β –511C/T, and IL-1β + 3953C/T were significantly associated with suicidal ideation within 2 weeks after ACS, but these associations did not reach significance after the Bonferroni correction in unadjusted analyses and after adjusting for covariance. However, no significant association between genetic polymorphisms and suicidal ideation was found at 1 year. Genetic predisposition, 5-HTTLPR s allele in particular, may confer susceptibility to suicidal ideation in ACS patients during the acute phase of ACS.


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