Inter- and intra-observer reproducibility of ADC measurements in esophageal carcinoma primary tumors
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Zhimin Ye1,*, Jun Fang1,*, Shujun Dai2, Tieming Xie3, Fangzheng Wang1, Zhun Wang1, Kai Li3, Zhenfu Fu1 and Yuezhen Wang1
1Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, China
2Department of Intensive Care Unit, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Department of Radiology, Zhejiang Cancer Hospital, Hangzhou, China
*These authors are considered as co-first authors
Zhun Wang, email: [email protected]
Zhenfu Fu, email: [email protected]
Keywords: esophageal carcinoma, diffuse weighted imaging, apparent diffused coefficient, reproducibility
Received: June 16, 2017 Accepted: August 17, 2017 Published: October 06, 2017
The apparent diffuse coefficient (ADC) may correlate with the treatment response to chemotherapy/radiotherapy in solid tumors. Our aim was to determine the inter- and intra-observer reproducibility of ADC measurements in primary esophageal squamous cell carcinoma (ESCC). ADCs were blindly measured in 31 patients diagnosed with ESCC by two observers before treatment (pre-ADC) and after 5th fraction radiotherapy (intra-ADC) twice with a 2-week interval. The mean pre-ADC of primary tumors was 1.25±0.22 and 1.27±0.23 (in 10−3mm2/s) from observer A for measurements 1 and 2, respectively, and the intra-observer measurements were -0.02 bias vs. -0.13-0.09 limits of agreement. From observer B, the mean pre-ADC varied between 1.25±0.23 and 1.27±0.23 (in 10−3mm2/s) for measurements 1 and 2, respectively, and intra-observer measurements were -0.02 bias vs. -0.17~0.16 limits of agreement. The mean pre-ADC of primary tumors was 1.26±0.24 (in 10−3mm2/s) from observers A and B, and inter-observer measurements were 0.01 bias vs. -0.09-0.09 limits of agreement, revealing a low inter-observer variance. Similar measurements of the intra-SD parameters showed that the pre- and intra-ADC of primary tumors differed significantly. Thus ADC measurements may have sufficient inter-observer and intra-observer reproducibility to measure primary tumor responses to treatment, and the ADCs before and during treatment differed.
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