Research Papers:

Pelvic recurrence after definitive surgery for locally advanced rectal cancer: a retrospective investigation of implications for precision radiotherapy field design

Chao Li, Yinju Zhu, Tong Tong, Ye Xu, Yun Guan, Jingwen Wang, Huankun Wang and Ji Zhu _

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Oncotarget. 2017; 8:95973-95980. https://doi.org/10.18632/oncotarget.21616

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Chao Li1,2,*, Yinju Zhu3,*, Tong Tong2,4, Ye Xu2,5, Yun Guan1,2, Jingwen Wang1,2, Huankun Wang3 and Ji Zhu1,2

1Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China

2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

3Department of Radiation Oncology, Dalian Third People’s Hospital Affiliated to Dalian Medical University (Dalian Cancer Hospital), Dalian, China

4Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China

5Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China

*These authors have contributed equally to this work

Correspondence to:

Ji Zhu, email: [email protected]

Huankun Wang, email: [email protected]

Keywords: pelvic recurrence; advanced rectal cancer; radiotherapy; total mesorectal excision; radiation toxicity

Abbreviations: Multi-disciplinary treatment (MDT); Radiotherapy (RT); Total mesorectal excision (TME); Clinical target volume (CTV); Lateral lymph node (LLN)

Received: June 24, 2017    Accepted: August 17, 2017    Published: October 07, 2017


Background: To analyze the local distribution of pelvic recurrence after total mesorectal excision, with a view to simplifying the formulation of optimal individualized radiotherapy plans.

Methods: We retrospectively investigated the data of 168 patients diagnosed with recurrent pelvic cancer treated at Fudan University Shanghai Cancer Center between January 2008 and December 2012. The following were collected depending on availability: operative report, histological report, specimen photographs, initial preoperative images, images confirming local recurrence, and clinical history.

Results: A total of 203 lesions of local recurrence were identified. The most common sites of pelvic recurrence were the mesorectum, including the anastomotic stoma in 53.0% of cases; presacral space in 27.4%, and pelvic floor and perineum in 21.4% the cases. Recurrence was most common in the lower pelvic region (i.e., below the upper border of the acetabulum), accounting for approximately 76.2% (128 cases) of cases. In patients with mid-rectal and distal rectal carcinoma, <5% had relapse in the upper pelvis, and in those with distal rectal cancer, no recurrence occurred in the external iliac and inguinal area.

Conclusions: Patients with pelvic cancer may benefit by individualized treatment plans aimed at achieving a balance between tumor control and minimal risk of irradiation-induced toxicity.

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