Oncotarget

Research Papers:

Genetic polymorphisms in caveolin-1 associate with breast cancer risk in Chinese Han population

Meng Wang, Tian Tian, Xiaobin Ma, Wenge Zhu, Yan Guo, Zhao Duan, Jiangbo Fan, Shuai Lin, Kang Liu, Yi Zheng, Qianwen Sheng, Zhi-Jun Dai and Huixia Peng _

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Oncotarget. 2017; 8:91654-91661. https://doi.org/10.18632/oncotarget.21560

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Abstract

Meng Wang1,*, Tian Tian1,*, Xiaobin Ma1,*, Wenge Zhu2, Yan Guo3, Zhao Duan4, Jiangbo Fan4, Shuai Lin1, Kang Liu1, Yi Zheng1, Qianwen Sheng1, Zhi-Jun Dai1 and Huixia Peng4

1Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

2Department of Biochemistry and Molecular Medicine, The George Washington University Medical School, Washington, DC, USA

3School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, China

4Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

*These authors have contributed equally to this work

Correspondence to:

Huixia Peng, email: phx02@163.com

Zhi-Jun Dai, email: dzj0911@xjtu.edu.cn

Keywords: caveolin-1, polymorphism, breast cancer, risk

Received: March 07, 2017     Accepted: May 22, 2017     Published: October 06, 2017

ABSTRACT

Caveolin-1(CAV-1) was demonstrated to be a tumor suppressor gene and be implicated in the development of breast cancer (BC). Numerous potentially functional polymorphisms in CAV-1 have been identified, but their effects on BC were not clear. This case-control study aims to evaluate the relationship between CAV-1 polymorphisms and BC risk. 560 BC patients and 583 healthy controls were enrolled in the present study, all from Chinese Han population. We detected 3 single nucleotide polymorphisms (rs3807987, rs1997623, and rs7804372) in CAV-1 using the Sequenom MassARRAY method. The association between CAV-1genotypes and BC risk was assessed in six genetic models by calculating the odds ratio (OR) and 95% confidence intervals (95% CIs) with χ2-test. The CAV-1 rs3807987 polymorphism was observed to increase the risk of BC And the A allele of rs3807987 relates to a larger tumor size (≥2cm) and lower incidence of PR-positive BC while the AA genotype of rs7804372 associates with a higher ER and Her-2 positive rate among BC patients. In addition, Ars1997623Grs3807987Trs7804372 haplotype was linked to a decreased risk of BC (OR =0.64, 95%CI=0.44-0.93), whereas Crs1997623Ars3807987Trs7804372 haplotype was related to an increased BC risk (OR =1.74, 95%CI=1.04-2.92). Our study suggests that CAV-1 rs3807987 can increase the BC risk among Chinese Han women. And the rs3807987 and rs7804372 in CAV-1 may serve as predictors for prognosis of BC.


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