β2GPI exerts an anti-obesity effect in female mice by inhibiting lipogenesis and promoting lipolysis
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Shangwen Dong1,2, Miao Qi1, Ying Wang1,3, Liming Chen3, James Crofton Weaver4, Steven Antony Krilis1,* and Bill Giannakopoulos1,5,*
1Department of Infectious Diseases, Immunology and Sexual Health and Department of Medicine, St George Hospital, University of New South Wales, New South Wales, Sydney, Australia
2Department of Cardiothoracic Surgery, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, China
3Laboratory of Hormones and Development (Ministry of Health), Metabolic Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China
4Department of Cardiology, St George Hospital, New South Wales, Sydney, Australia
5Department of Rheumatology, St George Hospital, New South Wales, Sydney, Australia
*These authors have contributed equally to this work
Bill Giannakopoulos, email: [email protected]
Keywords: apolipoprotein H, β2-glycoprotein I, obesity, sexual dimorphism, lipogenesis
Received: May 18, 2017 Accepted: July 12, 2017 Published: October 04, 2017
In humans, males compared to females have increased visceral adipose tissue which contributes to their increased risk of early death. Mice display analogous sexual diamorphism whereby females are protected from weight gain when fed a high fat diet compared to males. A role has recently been reported for β2-glycoprotein I, an abundant plasma protein, in healthy leanness in humans. In this study we investigated the role of β2-glycoprotein I in fat metabolism in male and female mice fed a normal chow or high fat diet. We have made a number of novel insights into factors contributing to sexual diamorphism in obesity. Female wild type mice are protected from obesity when fed a high fat diet due to down regulation of lipogenesis in the visceral adipose tissues. This down regulation is due to β2-glycoprotein I as female mice deficient in this protein have increased levels of lipogenesis enzymes in their visceral adipose tissues with an accompanying increase in weight compared to female wild type controls. Understanding female specific regulators of obesity may lead to sex specific anti-obesity therapies to address this major health problem.
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