Oncotarget

Research Papers:

This article has been corrected. Correction in: Oncotarget. 2018; 9:25750.

Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice

Haobin Cai, Yijie Wang, Jiayang He, Tiantian Cai, Jun Wu, Jiansong Fang, Rong Zhang, Zhouke Guo, Li Guan, Qinkai Zhan, Li Lin, Yao Xiao, Huafeng Pan and Qi Wang _

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Oncotarget. 2017; 8:92621-92634. https://doi.org/10.18632/oncotarget.21515

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Abstract

Haobin Cai2,1, Yijie Wang1, Jiayang He1, Tiantian Cai1, Jun Wu1, Jiansong Fang1, Rong Zhang1, Zhouke Guo2, Li Guan1, Qinkai Zhan1, Li Lin3, Yao Xiao4, Huafeng Pan1 and Qi Wang1

1Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China

2Department of Neurology & Psychology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen 518033, China

3Guangzhou University of Chinese Medicine, Guangzhou 510405, China

4Guangzhou Medical University, Guangzhou 510182, China

Correspondence to:

Qi Wang, email: [email protected]

Huafeng Pan, email: [email protected]

Keywords: dementia, bajijiasu, amyloid-β, cognitive impairment, APP/PS1 mice

Received: July 13, 2017     Accepted: September 03, 2017     Published: October 04, 2017

ABSTRACT

Alzheimer's disease (AD) is a progressive neurological degenerative disease. The main clinical manifestations of AD include progressive cognitive impairment and alteration of personality. Senile plaques, neuroinflammation, and destruction of synapse structure stability are the main pathological features of AD. Bajijiasu(BJJS) is extracted from Morinda Officinalis, a Chinese herb. In this study, we explored the effect of BJJS on AD from many aspects in APPswe/PSEN1ΔE9 (APP/PS1) double transgenic mice. The Morris water maze and novel object recognition tests results showed that BJJS could significantly improve the learning and memory abilities in APP/PS1 mice. BJJS treatment increased the level of insulin degradation enzyme (IDE) and neprilysin (NEP) and decreased the level of β-site app cleaving enzyme 1(BACE1) in the brain of APP/PS1 mice. BJJS-treated APP/PS1 mice appeared to have reductions of Aβ deposition and senile plaques, and showed higher levels of neurotrophic factors in the brain. We also found that BJJS had an inhibitory function on neuroinflammation in APP/PS1 mice. In addition, the synapse structure relevant proteins were elevated in the brain of BJJS-treated APP/PS1 mice. The present results indicated that BJJS could attenuate cognitive impairment via ameliorating the AD-related pathological alterations in APP/PS1 mice. These findings suggest that BJJS may be a potential therapeutic strategy in Alzheimer's disease.


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