Exogenous melatonin in the treatment of pain: a systematic review and meta-analysis
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Chaojuan Zhu1,2,*, Yunyun Xu1,*, Yonghong Duan1,*, Wei Li3, Li Zhang1, Yang Huang1, Wei Zhao1, Yutong Wang1, Junjie Li1, Ting Feng1, Xiaomei Li4, Xuehui Hu2,5 and Wen Yin1
1Department of Emergency Medicine, Xijing Hospital, The Fourth Military Medical University, Xi’an 710032, China
2Department of Nursing, Xijing Hospital, The Fourth Military Medical University, Xi’an 710032, China
3Department of Human Anatomy, Histology and Embryology, The Fourth Military Medical University, Xi’an 710032, China
4Faculty of Nursing, College of Medicine, Xi'an Jiaotong University, Xi’an 710049, China
5Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi’an 710032, China
*These authors contributed equally to this work
Wen Yin, email: firstname.lastname@example.org
Xuehui Hu, email: email@example.com
Keywords: melatonin, pain, brain-derived neurotrophic factor, meta-analysis
Received: August 09, 2017 Accepted: September 20, 2017 Published: October 05, 2017
Melatonin is an important hormone for regulating mammalian circadian biology and cellular homeostasis. Recent evidence has shown that melatonin exerts anti-nociception effects in both animals and humans. However, according to clinical trials, the anti-nociception effects of melatonin are still controversial. The aim of this meta-analysis was to investigate the anti-nociception effects of melatonin premedication. The primary outcome was the effects of melatonin on pain intensity. The secondary outcomes included the number of patients with analgesic requirements, total analgesic consumption, and brain-derived neurotrophic factor (BDNF) levels. In total, 19 studies were included in the current meta-analysis. The pooling data show that melatonin significantly decreased the pain intensity, as evidenced by the pain scores. Moreover, melatonin administration also reduced the proportion of patients with analgesic requirements and BDNF levels. However, the effects of melatonin on total analgesic consumption still require further confirmation. Collectively, the current meta-analysis supports the use of melatonin for anti-nociception.
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