Oncotarget

Research Papers:

Red blood cell distribution width as a predictor of survival in nasal-type, extranodal natural killer/T-cell lymphoma

Huaichao Luo, Xiaoying Quan, Xiao-Yu Song, Li Zhang, Yilin Yin, Qiao He, Shaolei Cai, Shi Li, Jian Zeng, Qing Zhang, Yu Gao and Sisi Yu _

PDF  |  HTML  |  How to cite

Oncotarget. 2017; 8:92522-92535. https://doi.org/10.18632/oncotarget.21439

Metrics: PDF 1441 views  |   HTML 2134 views  |   ?  


Abstract

Huaichao Luo1,*, Xiaoying Quan2,*, Xiao-Yu Song1,*, Li Zhang1,*, Yilin Yin3,*, Qiao He1, Shaolei Cai4, Shi Li1, Jian Zeng1, Qing Zhang1, Yu Gao1 and Sisi Yu2

1Department of Clinical Laboratory, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China

2Department of Medical Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China

3Department of Biology, The Northeastern University, Huntington Ave, Boston, MA, USA

4Radiotherapy Center, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China

*These authors have contributed equally to this work

Correspondence to:

Sisi Yu, email: [email protected]

Huaichao Luo, email: [email protected]

Keywords: red blood cell distribution width (RDW), extranodal natural killer (NK)/T-cell lymphoma, predictor, survival, radiotherapy-based treatment

Received: June 12, 2017     Accepted: August 26, 2017     Published: September 30, 2017

ABSTRACT

We retrospectively enrolled 191 nasal-type, extranodal natural killer/T-cell lymphoma (ENKTL) patients newly diagnosed from 2008 to 2016 at the Sichuan Cancer Hospital, in order to evaluate the relationship between disease outcomes, demographic and clinical factors, and red blood cell distribution width (RDW). C-index, fisher’s exact test, univariate analysis, and cox regression analysis were applied. The median age of patients was 44 years and 134 (70%) were men. The cutoff of RDW was 46.2 fL determined by Cutoff Finder. Patients with RDW≤46.2 fL had significantly better progression-free survival (PFS) (3-year PFS, 80.4% vs. 63.1%; P=0.01) and overall survival (OS) (3-year OS, 83.2% vs. 65.5%; P=0.004) than those with RDW>46.2 fL. Multivariate analysis demonstrated that elevated RDW is an independent adverse predictor of OS (P=0.021, HR=2.04). RDW is an independent predictor of survival outcomes in ENKTL, which we found to be superior to both the prognostic index of natural killer lymphoma (PINK) and the Korean Prognostic Index (KPI) in discriminating patients with different outcomes in low-risk and high-risk groups (all P < 0.05). The new models combining RDW with the International Prognostic Index (IPI), KPI, and PINK showed more powerful prognostic value than corresponding original models. RDW represents an easily available and inexpensive marker for risk stratification in patients with ENKTL treated with radiotherapy-based treatment. Further prospective studies are warranted to confirm the prognostic value of RDW in ENKTL.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 21439