Research Papers:

Aggressiveness pattern and second primary tumor risk associated with basaloid squamous cell carcinoma of the larynx

Filippo Ricciardiello, Michele Caraglia _, Brigida Iorio, Teresa Abate, Mariarosaria Boccellino, Giuseppe Colella, Flavia Oliva, Pierpaolo Ferrise, Silvia Zappavigna, Mario Faenza, Giuseppe A. Ferraro, Giulio Sequino, Giovanni Francesco Nicoletti and Massimo Mesolella

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Oncotarget. 2017; 8:95791-95798. https://doi.org/10.18632/oncotarget.21327

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Filippo Ricciardiello1, Michele Caraglia3, Brigida Iorio2, Teresa Abate1, Mariarosaria Boccellino3, Giuseppe Colella4, Flavia Oliva1, Pierpaolo Ferrise1, Silvia Zappavigna3, Mario Faenza4, Giuseppe A. Ferraro4, Giulio Sequino1, Giovanni Francesco Nicoletti4 and Massimo Mesolella2

1Division of Otolaryngology, “A. Cardarelli” Hospital, Naples, Italy

2Department of Neurological, Reproductive and Odontostomatological Sciences, University “Federico II” of Naples, Naples, Italy

3Department of Biochemistry, Biophysics and General Pathology, University of Campania “L. Vanvitelli”, Naples, Italy

4Department of Medical, Surgical and Dental Specialties, University of Campania “L. Vanvitelli”, Naples, Italy

Correspondence to:

Michele Caraglia, email: [email protected], [email protected]

Keywords: laryngea lbasaloid squamocellular carcinoma (BSCC); prognosis of laryngeal basaloid squamous cell carcinoma; mortality of laryngeal BSCC; loco-regional recurrence in laryngeal BSCC

Received: July 26, 2017    Accepted: August 23, 2017    Published: September 28, 2017


Basaloid squamous cell carcinoma (BSCC) is a rare, aggressive and distinct variant of squamous cell carcinoma (SCC) of the upper respiratory and digestive tract. We have evaluated disease specific survival (DSS) and overall survival (OS) through Kaplan-Meier method and mortality risk through univariate statistical analysis of Cox in 42 cases of BSCC and other 42 of laryngeal SCC (LSCC) matched for both age and sex. We demonstrated that laryngeal BSCC is a more aggressive tumor than LSCC as is associated to higher nodal recurrence of pathology (5 vs 2 patients, overall risk, OR 2.7), a reduced survival (median survival 34 vs 40 months, OR 3.2 for mortality); in addition, basaloid patients have a higher risk to be affected by second primary tumors (13 vs 3 patients, OR 5.8) and a higher probability to die for this second tumor (Hazard Risk, HR 4.4). The analysis of survival shows an increased mortality risk concurrent with the parameters assessed by univariate analyses that assume a predictive and statistical significance in second tumor and grading in basaloid LSSC.

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