Case Reports:

Bendamustine plus rituximab is an effective first-line treatment in hairy cell leukemia variant: a report of three cases

Andrea Visentin, Silvia Imbergamo, Federica Frezzato, Marco Pizzi, Roberta Bertorelle, Edoardo Scomazzon, Tamara Berno, Marcello Riva, Elisa Piva, Monica Facco, Francesco Piazza, Gianpietro Semenzato and Livio Trentin _

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Oncotarget. 2017; 8:110727-110731. https://doi.org/10.18632/oncotarget.21304

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Andrea Visentin1,2, Silvia Imbergamo1, Federica Frezzato1,2, Marco Pizzi3, Roberta Bertorelle4, Edoardo Scomazzon1, Tamara Berno1, Marcello Riva1, Elisa Piva5, Monica Facco1,2, Francesco Piazza1,2, Gianpietro Semenzato1,2 and Livio Trentin1,2

1Hematology and Clinical Immunology Unit, Department of Medicine, University of Padua, Padua, Italy

2Venetian Institute of Molecular Medicine, Centro di Eccellenza per la Ricerca Biomedica Avanzata, Padua, Italy

3General Pathology and Cytopathology Unit, Department of Medicine, University of Padua, Padua, Italy

4Immunology and Molecular Diagnostic Oncology Unit, Veneto Institute of Oncology IOV-IRCSS, Padua, Italy

5Unity of Laboratory Medicine, University of Padua, Padua, Italy

Correspondence to:

Livio Trentin, email: [email protected]

Keywords: HCL, HCL variant, bendamustine, BR, treatment naive

Received: April 21, 2017     Accepted: September 15, 2017     Published: September 28, 2017


Hairy cell leukemia variant (HCLv) is a chronic lymphoproliferative disorder classified as a provisional entity in the 2016 WHO Classification of Lymphoid Tumors. HCLv is characterized by unfavorable prognosis, low complete remission rates and limited disease control following classical hairy cell leukemia-based regimens. In this study, we report 3 cases of elderly patients with treatment-naive, TP53 un-mutated HCLv, who were effectively treated with four cycles of bendamustine plus rituximab. The regimen was completed in all the patients with acceptable toxicity. All patients achieved a complete clinical response with no evidence of residual disease at bone marrow biopsy and flow-cytometry examination. After a median follow-up of 19 months, the 3 subjects are still in complete remission. In this work, bendamustine plus rituximab proved to be an effective and feasible first-line treatment strategy for elderly patients with TP53 un-mutated HCLv.

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